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We have multiple postdoc positions available in my group at NYU. Join us if you're interested in complex trait genetics and biology. More information about the lab on our website: mostafavilab.org med.nyu.edu/research/postd…

How do genetic perturbations change cells? How are these effects shaped by cell type and dosage? How do we best extract insight from modern massive perturbation atlases? Im pleased to share a new preprint where we develop a suite of statistical approaches to these Qs (link below)

How constrained is each gene in the human genome? Our work on estimating gene constraint using loss-of-function mutations along with gene features (expression patterns across tissues, protein language model embeddings, etc...) is now officially out! 🧵/8 nature.com/articles/s4158…

Exciting news! OpenTn5 is live on @biorXiv - we introduce our robust open-source protocol for producing multi-purpose Tn5 transposase. But what is Tn5? 🧵 1/11 biorxiv.org/content/10.110…

Levels of gene expression matter! So how can you control a transgene precisely? Is there a tool that can ensure uniform control & the ability to adjust the setpoint of expression from a single promoter? Introducing DIAL! 🧵 (1/n) Link: doi.org/10.1101/2024.0…

We collected results from across the field to show how common that measurement is. So many studies in so many systems, and each correcting for measurement error. Co-localization controls have demonstrated that you can measure distances as little as 50nm.

Aging in humans in non-linear. Incredible Nature Aging study by Michael Snyder, PhD. nature.com/articles/s4358… Coincidentally the 1st wave of deregulation occurs at ~44 years, which also happens to be the median age of receiving the 1st R01 for many investigators. Grant writing 👉🏽 Aging

It is challenging to study the ability of transcription factors to engage their motifs in the cell. We tried to address this in our new study together with Marco (Marco Pregnolato), Schübeler Lab, and FMI science: cell.com/molecular-cell…

In Cell Stem Cell: a tribute to Charles “Chuck” K.F. Chan (1975–2024). Thank you Tom Ambrosi and Mike Longaker for remembering a brilliant and kind scientist and Stanford Medicine colleague gone far too soon: sciencedirect.com/science/articl…