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Had a wonderful experience at the Fall National Meeting of the American Chemical Society (ACS). Thankful to IUPUI Honors College for support! @IUPUIHonors

I know we’re all desperate to find out the result but Trump’s slow death by paper cuts is sublimely poetic

When your leaving group just won't leave, you just have to use the SN2 mechanism with a strong nucleophile. Got to say I'm liking the stereospecific inversion of policy that gives though.

Happy new year to all!

Donald Trump’s been permanently suspended by Twitter – 23 favourite jokes thepoke.co.uk/2021/01/09/don…

"Science is not the cold solving of problems. ... It is an act of love." Frances Arnold gave us chills with her deeply inspiring speech accepting the nomination by President Donald J. Trump Joe Biden to serve as co-chair of PCAST. youtu.be/KevRVvP2-_M?t=…

A lovely dinner celebrating teaching biochemistry! The best TAs are from BMB Caltech.

The Rees lab is excited to share their work on homocitrate-compromised states of nitrogenase. This work emphasizes the importance of the homocitrate in catalysis & reveals a previously uncharacterized endogenous protein binding partner for nitrogenase. nature.com/articles/s4146…

!!! Proud to be part of this work on the first enzyme I ever studied, AlkB! Even though my crystals never diffracted :) Congrats to the awesome team behind this Barnard College StanfordMCP!

Great song open.spotify.com/track/2yAVzRiE…

Our latest review of a diverse family of ATPases is now online Journal of Molecular Biology , as part of a special issue honoring Peter Wright’s contributions to JMB. Had a great time writing this with the amazing Dr. Ailiena Maggiolo! Clemons Lab @Caltech @reeslab Caltech Chemistry & Chemical Engineering sciencedirect.com/science/articl…

Fear of retaliation in academia goes well beyond our workplace. During the Lindau meeting, Kurt Wüthrich (Nobel prize for NMR) argued against the meeting’s focus on diversity and even mentioned that discrimination against men is real. Here, I would just cite the statistics that

Gibbs is timeless. Thermodynamics after him has remained unchanged in its aim and method. Carnot and Clausius invented entropy, Boltzmann and Planck discovered what entropy is, and Gibbs made entropy useful. We are all Gibbsians.

Check out the newly published report on the structural basis of phage-encoded protein inhibition of a peptidoglycan biosynthetic enzyme by Anna Karen Orta and colleagues! Clemons Lab @Caltech Absolutely stunning work!

New research in Science reveals how a three-protein complex allows bacteriophages to kill and lyse host cells. The results may be useful in developing effective phage therapeutics. 📄: scim.ag/3o3 #SciencePerspective: scim.ag/3o2

New in Science: Researchers have created a synthetic platform for studying the coevolution of interacting proteins. The platform could prove useful in developing new protein complexes that recognize a variety of molecules. scim.ag/3DI

My graduate school advisor who is a very accomplished and renowned scientist told me that once a day he’ll open a random textbook to a random page and go over the basics: every time he discovers something new. You’re never too old or advanced to revisit the fundamentals.

Oke, the AlphaFlow paper is awesome: AlphaFold Meets Flow Matching for Generating Protein Ensembles arxiv.org/abs/2402.04845 Just watch how AlphaFlow's ensemble reproduces details of MD. Weights + code github.com/bjing2016 We have it in the reading group on Mon 11am EST! 1/2