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VENTURE trial shows Setmelanotide (MC4R agonist) is effective in very young children (age 2-5 yrs) with POMC, PCSK1 and LEPR deficiencies and in Bardet-Biedl syndrome. Trial results after 12 months, published in Lancet Diabetes and Endocrinology doi.org/10.1016/S2213-…

I highlighted my concerns about the industry last year in an email to the CEOs of the FCA and the CMA. My email was read over 1200 times in several countries but I never got a reply. Makes you wonder. Is PMI too important to be allowed to fail given the state of the NHS?

Association of polygenic scores for neuropsychiatric traits with self-reported professions based on analysis of 420k individuals from UK Biobank and Million Veteran Program. Look at the 'arts & design' category. Artistic talent comes at a cost--a piece of your mind :) Voloudakis

Great to see this call for action about clinical academic career crisis. ukri.org/news/report-ca…

Agree that it’s great to see this. Delivering 2.3 will be key. I don’t doubt the funders desire to see this happen. I worry about the reality of commitment from NHS. Colleges and particularly HEE, which seems to be intent on stifling excellence and academic aspiration

Our latest effort in mapping the human hypothalamus: nature.com/articles/s4158… Inst Metabolic Science-Metabolic Research Labs Max Planck Institute for Metabolism Research @gilesyeo Georgina Dowsett John Tadross

Have you got a history of heart disease and/or cancer? Or are you the relative of someone who has? Our CardioOncology research group is gathering the public's opinion on what our priorities should be! ✅ only takes 15mins ✅ completely confidential forms.office.com/e/khM0e5w48g

Thanks to the reviewers 🙏 Also, we’re looking for a Postdoc to explore how obesity-associated genetic variants impact hypothalamic circuits using CRISPR-based Perturb-seq & in vivo metabolic phenotyping candidate.hr-manager.net/ApplicationIni… #neuroscience #obesity 3/3

' people.com/pregnant-woman… via People. Such a tragic story. Hopefully, thanks to recent science, we will have effective therapy. Inst Metabolic Science-Metabolic Research Labs Marlena Fejzo Sam Lockhart

For International Women’s Day, we are celebrating the women of the Inst Metabolic Science-Metabolic Research Labs, the MRC Epidemiology Unit and GDAR Network. Meet Professor Sue Ozanne lab, Director of the IMS-MRL & Professor of Developmental Endocrinology 👉 bit.ly/3XqX7vy #AccelerateAction #IWD2025

We are recruiting a student for a really exciting PhD project on understanding how high plasma suPAR predicts poor outcome in patients with ARDS Danny McAuley QUB Critical Care & Respiratory Research Group Wellcome-Wolfson Institute Experimental Medicine - any questions please get in touch! (open to UK and RoI) findaphd.com/phds/project/u…

Delighted to see this published in Euro J Endocrinology after many years of work Forever grateful to Prof Márta Korbonits Lab for giving me the chance to work on this Reassessing the role of the p.(Arg304Gln) missense AIP variant in pituitary tumorigenesis academic.oup.com/ejendo/article…

Very excited to finally share our work using subcellular proteomics to look at insulin-stimulated protein movement in adipocytes! 🧵below: (1/5) biorxiv.org/content/10.110… Daniel Fazakerley Inst Metabolic Science-Metabolic Research Labs

Please check out Liv's preprint and thread below!

Our latest paper, published today in FEBS Letters is a chemical biology study on development of drugs selectively targeting HDAC6 with demonstration of efficacy in a human model of liver fibrosis. Congratulations to all authors. febs.onlinelibrary.wiley.com/doi/10.1111/fe…

Interested in undertaking a PhD to contribute to the understanding of the links between insulin resistance and cardiovascular disease? Apply to join my lab at the RVC with this fully-funded PhD studentship.

This is a really important point. Nobody is saying come off the diet. I myself have been low-carb/keto since 2018. What most of us are advocating is that for those people who are on these diets and find benefit and also have these increases in LDLc/ApoB, do not assume that it is

I lost the count of how many posts I saw about the Keto-CTA study the last days. One issue that directly relates to the lack of association between ApoB/LDL-C and plaque progression that I haven't seen anyone talk about is collider bias👇

John Mandrola, MD How would you interpret the genetic findings? jamanetwork.com/journals/jamac… sciencedirect.com/science/articl…