📢An engineering theory of evolution! First preprint out from Sim Castle introducing the concept of 'evotype' to enable us to reason about & design the evolutionary potential of engineered biological systems. Claire G Bristol BioDesign Institute #synbio #evolution preprints.org/manuscript/202…

I'm sorry but this year it should be called "Lobby Universities, Funders and Governments To Actually Give a Damn About Postdocs Week" here's why... ⬇️

🥳 Refined and expanded... our updated “Engineering Theory of Evolution” This underpins a number of tough experimental projects in the lab as we explore how evolution can become become integrated into large-scale biosystem design! Sim Castle Claire G #synbio preprints.org/manuscript/202…

Just posted a photo instagram.com/p/CP0OPwmpuOO/…

My first paper is out today in Nature Comms "Towards an engineering theory of evolution"

One of the biggest inspirations for my art, music, and science is the beauty that exists between order and chaos. This is the region where life can evolve, where meaning emerges from information, and where consciousness is possible. instagram.com/p/CP2cHi8pueR/…

LSB scientists develop the ‘evotype’ to help unlock the power of evolution for better engineering biology. Incredible work from Sim Castle, Claire G, and Thomas Gorochowski! Find out more at the link below: bristol.ac.uk/news/2021/june…

Great work, Joshua. Extra thanks for all the work you did on revisions for this during your EPSRC fellowship!

I wrote a blog post about the paper I wrote with Thomas Gorochowski and Claire G #evotype #evolutionaryengineering bioengineeringcommunity.nature.com/posts/engineer…

Turns out several creationist blogs have (wilfully?) misunderstood our paper. For the record: the thesis is that engineers can design *with* evolution, NOT that evolution came about through engineering. nature.com/articles/s4146…

"It took years — eight years and counting in exile — for me to realize that I was missing the point: we talk about conspiracy theories in order to avoid talking about conspiracy practices, which are often too daunting, too threatening, too total." edwardsnowden.substack.com/p/conspiracy-p…

New paper out in @NAR_Open on efficient use of dCas12a for multiplexed gene regulation in yeast 🥳 Epic effort lead by @KlaudiaCiurkot at @DSM as part of the EU SynCrop ETN. Great foundation for future genetic circuit design! #synbio #crispr Bristol BioDesign Institute doi.org/10.1093/nar/gk…

Can anyone recommend a Bristol-based children's charity to give small cash donations?

"carbon footprint" is a concept invented by BP to shift responsibility away from oil companies and onto individuals mashable.com/feature/carbon…

As always #IWBDA2021 was great! If you'd like to see what my lab is up to, my keynote is now available to watch online. I hope it sparks interest in some of you to go #beyondGFP and #engineerevolution! 🦠💻🛠️🦀 #synbio #biodesign #biocomputation youtube.com/watch?v=gyOI7F…

📢Latest paper out @NatComms "Massively parallel characterisation of engineered transcript isoforms using direct RNA sequencing" We learn to control flows along DNA by repurposing terminators as transcriptional valves! @co_evolver Bristol BioDesign Institute SynBio CDT nature.com/articles/s4146…

🚨In new work led by Sim Castle, we consider what it means to engineer something and what exactly the design process is. By linking to key engineering literature that has been overlooked by much of #synbio to date, we find evolution is a unifying concept. osf.io/urq9w/

Rhythmic Attractor, an album of biodelic music, is now on SoundCloud on.soundcloud.com/rwJQs

#Engineering is #evolution 🧐 ...perhaps? In the latest from the lab Nature Communications we explore what "#design" might mean when engineering biology and the unifying role of evolution. Work led by the brilliant Sim Castle with Michiel ☁️ #synbio doi.org/10.1038/s41467…

Latest paper, Engineering is Evolution, is now out in Nature Communications! It was great fun working on this one with Thomas Gorochowski and Michiel ☁️ doi.org/10.1038/s41467…