Tumour immunotherapy: lessons from predator–prey theory dlvr.it/SPpt5m

My mind continues to be blown by this paper from the Singer lab exploring the nature of CD4 and CD8 regulation of immunity. The Treg data alone give me so many ideas. nature.com/articles/s4159…

Today is a major milestone in cancer treatment history. It's been 10 years since Emily Whitehead became the first pediatric patient in the world to receive #CARTcell therapy, developed by Penn & in collaboration w/ Children's Hospital. Catch Emily on the TODAY tomorrow morning!

How can we improve CAR T cell therapy for solid tumors? Dr Marcela Maus group shows that cell adhesion is vital for optimal anti-tumor activity cell.com/med/fulltext/S…

Congratulations to the #NotchTx team, led by Dan Kirouac, on the release of this important paper. Herein we identify the key parameters and molecular benchmarks for CAR-T target product profiles. With these design criteria we can make better #CGT products! nature.com/articles/s4158…

Happy #InternationalWomensDay! We are going to take this opportunity to highlight some of the incredible #GairdnerAwards laureates who have made significant contributions to the health andd wellbeing of people around the world. #Thread 1/6

Happy to share the newest paper from our lab. Led by technician extraordinaire Aidan Tousley (soon to be an MD/PHD student!), this manuscript details our attempts to reimagine the structure of CARs to improve their specificity and efficacy. rdcu.be/c7avS

The MSL & @SBME_UBC's Dr. Peter Zandstra (Peter Zandstra) recently caught up with Dylan Neel, MD PhD, MD-PhD candidate from Harvard Medical School. Learn more about Dr. Zandstra's journey from #engineering to #Biotechnology. UBC Science biomarker.substack.com/p/lab-meeting-…

Nice article on 'How Does Leadership Influence Organizational Culture?' online.hbs.edu/blog/post/orga…

Thrilled to share our work in Nature Materials on profiling lymphoid tumor microenvironment & engineering Lymphoma organoids to define complex cell-TME crosstalks! Huge congrats to my PhD Shiv Shah & all collabs!! Thx NIH Wellcome Leap HOPE for support! nature.com/articles/s4156…

High-density microbioreactor process designed for automated point-of-care manufacturing of CAR T cells biorxiv.org/cgi/content/sh… #bioRxiv

Super fun writing this review w/@YaleMichaels & Lauren Durand ... great overview of past & future of allo t-cell therapies! Engineering T Cell Development for the Next Generation of Stem Cell-Derived Immunotherapies | GEN Biotechnology liebertpub.com/doi/10.1089/ge… Stem Cell Bioengineering Lab

🚨NEW-Tissue-resident memory CAR T cells w stem-like characteristics display enhanced efficacy against solid & liquid tumors. TGF-β-produced CAR-Trm harbor stem-like cells, could potentially persist, 🔼#'s differentiated resident memory progeny cells in tumors

Ever wondered what the equivalent of differential gene expression is for cell-cell communication ? Look no further...it's MultiNicheNet, the first statistically sound framework for multi-sample multi-condition comparison of intercellular communication 👉doi.org/10.1101/2023.0…

On the eve of my first day of residency, I’m excited to share (belatedly) that my PhD work has finally been published! Below, learn more about our strategy to create a universal CAR T cell therapy that acts independently of tumor-expressed antigens. (1/7) nature.com/articles/s4155…

Know someone who is good at managing people 😀and money 💸 in research? My team @SBME_UBC is looking for a lab manager 🧪🧫 Please RT and share with someone you think would be a good fit! Apply here: shorturl.at/ipBCN More about us: shakiba.bme.ubc.ca

A race has begun to prove the potential of CAR-T cell therapies in autoimmune diseases, with multiple agents now in clinical trials for lupus - find out more in this news article in the November issue bit.ly/46r7h1L

The November cover illustrates that the viscoelasticity of extracellular matrices can be altered to generate functionally distinct T-cell populations from T cells that received the same stimulation. go.nature.com/47r0Wnq rdcu.be/drbP7 [Paper]