Hifiasm is able to combine HiFi and ultra-long reads for high-quality assembly. It often assembles multiple human chromosomes in T2T and has been deployed by HPRC and other groups. If you wonder how that works in detail, see Haoyu's recent paper at rdcu.be/dHxG3

📣 I’m looking for a postdoc to work on exciting computational projects in mitochondrial genomics Yale Department of Genetics! Interested in human genomics, #mtDNA & improving our ability to link genetic variation to disease? Reach out or find me at #ESHG24! Details 👉 thelakelab.org/yale-genetics-…

Check out ProCapNet by Kelly Cochran, a robust, local sequence context deep learning model of base-resolution transcription initiation profiles (PRO-cap) that provides deep insights into the cis-regulatory code of initiation & more ... biorxiv.org/content/10.110… 1/

My new lab at Yale Biomedical Informatics & Data Science is looking for a couple of postdocs, students and RAs in bioinformatics, genomics, machine learning and related fields (postdocs.yale.edu/postdoctoral-a…). Heartfelt thanks to my mentor Heng Li and collaborators for their incredible support!

Yale Department of Genetics and Yale Center for Genomic Health is hiring a tenure-track faculty member in human genetics and/or computational genomics. Come and join this fantastic department!

Are you interested in doing PhD in Computational genomics and disease genetics? Do you have a valid JRF? Connect for more information. Please apply if you are eligible. Trivedi School of BioSciences, Ashoka University Koita Centre for Digital Health - Ashoka (KCDH-A) Ashoka University

Evo has been published in @Science! A true privilege to work with such an amazing team! So many exciting new experimental results in this emerging field of Generative Genomics, including AI generated and *validated* CRISPR-Cas systems and transposons

My preprint: Genealogy based trait association with LOCATER boosts power at loci with allelic heterogeneity medrxiv.org/content/10.110…

Our department is hiring!

Hifiasm 0.21.0 has been released. It now has a beta module for direct assembly of ONT R10 simplex reads. Initial tests with regular simplex reads show very promising results! github.com/chhylp123/hifi…

Happy to share that our Nucleotide Transformer (NT) Genomics AI work has been published in Nature Methods! 🚀 This new milestone caps years of innovative research by the InstaDeep team at the intersection of AI and DNA, the code of life. 📷 To read more:

🚨Looking for a postdoc! 🚨Excited to recruit a computational researcher to join my lab Yale Department of Genetics and work on exciting projects in human & mitochondrial genomics, building tools to link genetic variation to disease. Enquiries welcome! Details 👉 thelakelab.org/yale-genetics-…

New preprint on hifiasm (ONT)! We can now achieve near T2T human genome assembly using only ONT Simplex reads—in just half a day, with or without ultra-long sequencing. biorxiv.org/content/10.110…

If you want to check if a human gene has copy-number changes or lands in a complex region, try pangene.bioinweb.org. Recently updated with more and better assemblies.

Preprint on "Finding easy regions for short-read variant calling from pangenome data": arxiv.org/abs/2507.03718

Next week, we're headed to #ASHG2025! HPRC members will be sharing their latest research and insights throughout the week. See who's presenting ⬇️

Yale's new HGS PhD track 🧬 BIDS faculty expertise bridging genome biology with computational techniques: → Genome assembly algorithms → Privacy-preserving biomedical data methods → AI/ML for complex disease genetics Learn more: medicine.yale.edu/biomedical-inf…