Super excited to see this out!!! Published in Nature Communications (and open access!)🔥 Highly Pathway Selective #GPCR Signaling via Nanobody Tethering🦙💊 A 🧵

Authors Ross Cheloha, @shivdoesscience and colleagues demonstrate that tethering ligands to GPCR receptors via conjugation with binding nanobodies enables pathway-specific signaling nature.com/articles/s4146…

Not my usual outside the🪟view!!! Enjoying amazing talks and stunning views at #GRC phosphorylation and G-protein signaling networks 🧪🏞️

Wow--mind blown! "Computational design of soluble and functional membrane protein analogues" @BShoichet Bryan Roth nature.com/articles/s4158…

Had an amazing last week in NH at #GRC phosphorylation and G-protein mediated signaling networks. Great science, engaging talks, and new research ideas. A huge thank you to the #NIH Fellows Award for Research Excellence and the Cheloha Group at #NIDDK for making this possible!!!

New from Pharmechanics, a YouTube-based workshop on analyzing kinetic signaling data for GPCRs. Watch and learn how to do curve fitting on GPCR time course signaling data. youtu.be/m1WT9Mmso7Q?si…

My lab has multiple openings for those interested in doing some very cool science in beautiful Colorado! Research assistants (tech/lab manager level): cu.taleo.net/careersection/… Postdoctoral fellows: cu.taleo.net/careersection/… DM or email me if interested and 🙏 share broadly 🪃

Now published in PLOS Biology: How GRK kinases control #GPCR signaling in the #Hedgehog transduction cascade in primary #cilia. journals.plos.org/plosbiology/ar…

👩‍🔬 👨‍🔬 Join us for the 4th Transatlantic ECI GPCR Symposium this Thursday and Friday! Come for science done by ECIs, ask about current & future trends in lunch sessions, hear career panel discussion, and network! Last hours for registration: lnkd.in/dZ_NxBNa

Cryo-EM structure of GPR179, a GPCR crucial for visual signalin, reveals how its dimer architecture fits curved membranes . Kirill Martemyanov Lab nature.com/articles/s4146…

Excited to share new work from our lab led by Uyen Pham – “Location-biased β-arrestin conformations direct GPCR signaling.” We demonstrate that b-arrestins display distinct conformations in different subcellular locations in regulating ERK MAP kinases. biorxiv.org/content/10.110…

So she was first author on his key paper - in fact she's on most of his key papers, yet she didn't get the Nobel Prize, in spite of the fact they could have given 3 awards, not just 2. Explain to me how STEM is not institutionally sexist.

Congratulations to the 2024 #NobelPrize in Chemistry winners, Drs. David Baker, Demis Hassabis and John M. Jumper! Dr. Baker’s #NIH-supported work at UW Medicine building new kinds of proteins is an incredible example of the value of taxpayer investment in biomedical research.

Nobel Prize is NOT about h-index or citations. It is about the emergence of big new fields. So many posts discuss Nobel awardees. And so many misunderstand the Nobel Prize. 📍 A bit of clarification from my side: 1⃣ Nobel Prize is NOT about how useful your work is. It’s about

Degrader Tac-opedia 🔘PROTAC: E3 ligase-targeted proteolysis 🔘DUBTAC: Deubiquitinase stabilization 🔘LYTAC: Lysosome-targeted degradation 🔘Trivalent PROTAC: Multivalent E3 ligase 🔘AUTAC: Autophagy-targeted degradation 🔘RIBOTAC: RNA-targeted degradation 🔘RNA-PROTAC:

Here to put the “boo” in boo-orthogonal click chemistry—and maybe pull a few tricks (or treats)! 🎃🧪 Happy #Halloween from the lab! #SpookyScience #LabHalloween

Evaluation of Alphafold modeling for elucidation of nanobody-peptide epitope interactions biorxiv.org/content/10.110…