Single-cell omics has evolved rapidly, becoming essential in research, enhancing diagnosis accuracy, disease monitoring, and personalized therapies, promising breakthroughs in healthcare. PMID:40645168, Cell 2025, @Cell cell.com/cell/fulltext/… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Stomatin (STOM) expression spikes in osteoporosis patients & ovariectomized mice; STOM-deficient mice boast higher bone mass even post-ovariectomy. Curious? Share thoughts! PMID:40595453, Nat Commun 2025, Nature Communications doi.org/10.1038/s41467… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Neuronal membrane skeletons with periodic lattice structures, vital for function, are constantly remodeled by calcium signaling. PMID:40773558, Science 2025, Science Magazine doi.org/10.1126/scienc… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Biomolecular condensates boost Bacillus lipase activity 3-fold by altering environments and stabilizing its open, active form through precise pH buffering. PMID:40640131, Nat Commun 2025, Nature Communications doi.org/10.1038/s41467… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Nuclear deformability in BRCA1-deficient cells enhances PARPi sensitivity by 30% via increased DNA break mobility, driven by microtubules and SUN1/2 proteins—game changer? PMID:40527886, Nat Commun 2025, Nature Communications doi.org/10.1038/s41467… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Inhibitors targeting the allosteric site of HECT E3 ligase SMURF1 were identified via a large unbiased screen, paving the way for new therapeutic strategies against E3 ligase-related diseases. PMID:40179885, Cell 2025, @Cell cell.com/cell/fulltext/… #AI #Pharma #BioMed #RNA #ASHG

ATG7 protein crucial in immune cells to fight rising nontuberculous mycobacterial infections! Targets include Mycobacterium avium & Mycobacteroides abscessus. PMID:40730835, Nat Commun 2025, Nature Communications doi.org/10.1038/s41467… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Engineered from IscB, a compact RNA-editing platform offers superior activity to Cas13 without the harmful cytotoxicity, utilizing its natural affinity for ssDNA/RNA. PMID:40829585, Cell 2025, @Cell cell.com/cell/fulltext/… #AI #Pharma #BioMed #RNA #ASHG #ESHG

GPR3 forms constitutive homodimers in live cells. Cryo-EM shows AF64394 as a negative allosteric modulator that targets these GPR3 dimers, key for drug discovery! PMID:40866348, Nat Commun 2025, Nature Communications doi.org/10.1038/s41467… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Explore the nucleus with a new technique! Mapping 13 nuclear targets with nanometer precision reveals active/repressive states less than 1 micron apart. PMID:40593784, Nat Commun 2025, Nature Communications doi.org/10.1038/s41467… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Unlocking gene expression dynamics: A new approach combines Fluorescent Timer & machine learning to decode Foxp3 transcription, enhancing single-cell analysis precision. PMID:40595611, Nat Commun 2025, Nature Communications doi.org/10.1038/s41467… #AI #Pharma #BioMed #RNA #ASHG #ESHG

🚨 Discoveries in cardiac hypertrophy! Using data from 29,661 UK Biobank images, epistasis near genes like CCDC141 & IGF1R was identified. #GeneticsRevolution PMID:40473955, Nat Cardiovasc Res 2025 Stanford University doi.org/10.1038/s44161… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Mitochondria are vital for pluripotent stem cell (PSC) function. This study shows PSCs can survive days without mitochondria through enforced mitophagy, enabling innovative interspecies PSC fusions. Insights into mitochondrial roles in pluripotency may shape future therapies.

Mitochondrial genetics predict immune checkpoint efficacy in melanoma. Study: 1,225 patients from CheckMate-067 & IGIMC. PMID:40473950, Nat Med 2025, Nature Medicine doi.org/10.1038/s41591… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Optogenetic discovery reveals ISR modulators that enhance stress response without toxicity. Screening of 37 compounds highlights potential for targeting cancer, neurodegeneration, and viral infections. PMID:40651473, Cell 2025, @Cell cell.com/cell/fulltext/… #AI #Pharma #BioMed

Examining a 12-week HIIT impact on hippocampal integrity in Cannabis Use Disorder adults; unlocking brain health! PMID:40928796, JAMA Psychiatry 2025, JAMA Psychiatry doi.org/10.1001/jamaps… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Explore the new GlycanDIA workflow for glycomic analysis! Offers high sensitivity and precision using DIA, HCD-MS/MS, and staggered windows. Revolutionizing disease insights! PMID:40750788, Nat Commun 2025, Nature Communications doi.org/10.1038/s41467… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Dupilumab shows promise as a steroid-sparing therapy for managing cutaneous toxicities from antibody-drug conjugates in this case series. PMID:40736743, JAMA Dermatol 2025 doi.org/10.1001/jamade… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Discover a breakthrough in Chagas disease: TcMscS, a miniature channel from Trypanosoma cruzi, retains function with just a fraction of EcMscS's structure. Fascinating! PMID:40781240, Nat Commun 2025, Nature Communications doi.org/10.1038/s41467… #AI #Pharma #BioMed #RNA #ASHG #ESHG

STN1, linked to poor survival, boosts PDAC metastasis via ZEB1 transcription, driven by HOXB7. Unraveling these links could unlock new therapeutic paths. PMID:40841373, Nat Commun 2025, Nature Communications doi.org/10.1038/s41467… #AI #Pharma #BioMed #RNA #ASHG #ESHG