A new way to dampen the Mec1(ATR) checkpoint, mediated by Srs2 DNA helicase! Check out our paper by Nalini Dhingra at Xiaolan Zhao Lab @sloan_kettering in collaboration with professorantony Sahiti Kuppa Nilisha Pokhrel in PNASNews 1/3 pnas.org/content/118/8/…

A piece of good news, my new research on hepatitis B virus (HBV) is online today! Alexander Ploss, Princeton MolBio. nature.com/articles/s4146… HBV is a cancer virus that claims close to a million lives a year world wide. Hope HBV can be cured one day!

The reported shootings of Asian American women on Tuesday in Atlanta is an unspeakable tragedy – for the families of the victims first and foremost, but also for the AAPI community — which has been reeling from high levels of racial discrimination. bit.ly/3eKmNOf

Stop anti-Asian hate

New structural insights into the mysterious Smc5/6 complex, focusing on the KITE-Kleisin subcomplex. Nice collaboration between Xiaolan Zhao Lab and the Cho lab. Congrats to all authors. Shibai @sloan_kettering Journal of Molecular Biology sciencedirect.com/science/articl…

Our collaborative study from Dinshaw lab, Xiaolan Zhao Lab, Kentsis Research Group & Andrej Sali lab addresses the structures & functions of the Smc5/6 complex & is out now in PNAS. Congrats to all authors, including You Yu Shibai Zheng Ser Tanmoy Sanyal. 1/5 pnas.org/content/118/19…

Social DNAing Webinar is ready for the fall. We are excited to welcome 14 speakers. Tune in on Thursday morning and sign up at cancer.columbia.edu/research/progr…

We are excited to present our collaboration with @LabRemus @sloan_kettering showing how the 9-1-1 checkpoint clamp is recruited to 5' ss/dsDNA junctions, which arise following DNA damage. Preprint:biorxiv.org/content/10.110… 1/5

Thank @AgnelSfeir for a wonderful talk. Dr. Xiaolan Zhao Xiaolan Zhao Lab will tell us all about the SMC complex this week. Sign up at cancer.columbia.edu/research/progr…

Registration is open for FASEB Genetic Recombination & Genome Rearrangements conference (tinyurl.com/45bzpn6v)! Early Registration/housing Deadline: 7/14/2022. This 19th iteration of a high successful conference series will take place at Steamboat Spring (CO), 8/14-8/18/2022.

Happy to share our latest paper about how Smc5/6 complex clamps DNA. Great experience work with @You Yu, ⁦Xiaolan Zhao Lab⁩ @Petal Lab_SKI. pnas.org/doi/10.1073/pn…

I'm extremely excited to share our work uncovering the role of ORC sumoylation in fine-tuning origin licensing! Many thanks to our collaborators Catherine Fox Lab @LabRemus Nikhil Bhagwat @HunterMeiosis and of course Xiaolan Zhao Lab 1/3 genesdev.cshlp.org/content/early/…

Just got back from a great conference #GRGR22. Thank you to Xiaolan @Zhaolab_SKI and Neil @HunterMeiosis for putting together and giving me the opportunity to serve every speaker as the projectionist.

Congratulations, Gemma! Very well deserved!

Excited to see our latest paper published in Nature Communications! Here, we use single-molecule fluorescence & force microscopy to study the interaction of Smc5/6, a conserved eukaryotic SMC complex essential for genome maintenance, with different types of DNA 1/n nature.com/articles/s4146…

What a good news for thanksgiving day! It’s such a great collaboration experience with Shixin and Jeremy!

Happy to share our latest paper online just before thanksgiving day ⁦Nature Communications⁩ ! It’s such a great collaboration experience between ⁦LiuLab_Rockefeller⁩ and ⁦Xiaolan Zhao Lab⁩. Thanks to Shixin and Xiaolan, also learned a lot from Jeremy! nature.com/articles/s4146…

1/3 In case you missed tweets from Shibai, LiuLab_Rockefeller, checkout our collaborative work to address how the multi-functional Smc5/6 binds to different forms of DNA - hard to tackle for a large filamentous complex but single mol approach works well. rdcu.be/c0hFQ

In this study, Xiangzhou Meng et al. Xiaolan Zhao Lab describe how an antagonistic balance between Pol2’s exonuclease- and POPS-domain activities direct polymerase movement and genome replication in yeast. Read more about it here: ➡️genesdev.cshlp.org/content/early/…

We have a fully-funded postdoc position available! Please see below for a detailed description of the position if you are interested in joining our team 👇