🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

I'm thrilled to share our new study of the spatial evolution of Kras;p53-driven mouse lung adenocarcinoma! It's been fantastic leading this with Dian Yang & Sun_Dawei, and enjoying a long-standing collaboration with Jonathan Weissman's Lab Yosef Lab & Fei Chen Lab. biorxiv.org/cgi/content/sh…

We are seeking a Scientist to join our team in the Horns lab at Arc Institute and Stanford University! Fantastic opportunity to develop cutting-edge tech for tracking cellular state dynamics to unravel the mysteries of health and disease. Please RT! bit.ly/HornsLabScient…

The DelRosso Lab is starting UC San Francisco 1/2025 and is seeking applicants for a research postbac! We will be developing cutting edge high-throughput approaches to study the relationship between disordered protein interactions and transcription in human cells🔎 aprecruit.ucsf.edu/JPF05341

excited to share COMET! A scalable CRISPR approach we (Caroline Wilson) developed to identify multidomain proteins that modulate transcription at specific endogenous genomic loci. Arc Institute @ucsf doi.org/10.1101/2024.1…

Delighted to share our skin transposons paper now online Cell !#TransposableElements #mobileDNA #Regeneration #Skin #StemCell cell.com/cell/fulltext/… Congrats to outstanding postdoc Ying Lyu and our amazing team YounJoo, Ericka, Richa, MD Anderson-UTH Grad #proudPI! A big

This is the summary of what we have shown in this paper. The take-home message is that facultative heterochromatin is slowly formed by the H2Aub1-reading PRC2.2 complex in a stepwise manner. 10/11

🧵Epigenetics require the coordinated interplay of diverse proteins and mechanisms. To systematically explore this, we invented the COMBINE platform to quantify the effect of >50,000 pairs🧦of long epigenetic effectors on endogenous human transcription biorxiv.org/content/10.110…

Excited to share our first publication on the placenta in close collaboration with our colleagues in the Coyne Lab.  This work led by @madkeenen reveals remarkable nuclear heterogeneity arising in a common cytoplasm of the syncytiotrophoblast cell. elifesciences.org/reviewed-prepr…

Deaminase-assisted Fiber-seq (DAF-seq) has arrived! DAF-seq is an amplification-compatible version of #Fiberseq that resolves genetic and chromatin architectures with single-nucleotide, single-molecule, single-haplotype, and single-cell precision. biorxiv.org/content/10.110…

Our new preprint with S.Yoshida and B.Simons! Led by Arun Chakravorty, we leverage spatial information to resolve temporal dynamics in spermatogenesis! biorxiv.org/content/10.110… Also check out a complementary preprint by S.Y. and B.S using live imaging! biorxiv.org/content/10.110… (1/10)

Maybe this business school faculty member should do some self reflection on who can afford to do a PhD without a living wage and then reevaluate who really has the “privilege” here. What a horrendously bad take. stanforddaily.com/2024/11/10/sel…

In collaboration with William Allen and Xiaowei Zhuang, we have developed Perturb-multi: biorxiv.org/content/10.110…

This is (yet another) nice study from our neighbours in the Oudelaar lab MPI for Multidisciplinary Sciences and peers at Priority Program SPP2202 and @sfb1565, to which Mariano Barbieri added some of his dtailed bottom-up MD simulations to further rationalise experimental data. Read on. Hope to see it soon in print!

The lives of cells, recorded go.nature.com/4g2gRwG #Perspective by Amjad Askary, Wei Chen, Junhong Choi, Lucia Y. Du, ElowitzLab, @james_gagnon, Alex Schier, Sophie Seidel, Jay Shendure, Tanja Stadler & Martin Tran

🚀 New preprint from our lab, Ekaterina Krymova and Fabian Theis : UniversalEPI, an attention-based method to predict enhancer-promoter interactions from DNA sequence and ATAC-seq🌟 🔬 Key Highlights: - Predicts chromatin interactions across unseen cell types with no retraining. -

How does chromatin fold in different species? Is there an ubiquitous mechanism of chromatin folding in all species? We review published data to investigate the "Evolution and function of chromatin domains across the tree of life". rdcu.be/d1CxC

Are you a senior PhD student or recent grad seeking a postdoc opportunity? Apply to SUPR, Yale Cell Biology’s new initiative! Selected applicants will visit Yale to connect with potential mentors! Deadline: 1/10/2025. Apply: medicine.yale.edu/cellbio/postdo…

Excited to share our lab's first preprint: we used spatial transcriptomics to dissect how aging disrupts the cycling ovary! 🧵 This was an incredible team effort w/ Jennifer Garrison Tammy Lan David Fischer AlisonKochersberger Ruth Raichur Sophia Szady

11/ Interested in tissue dynamics, technology development, and computation? We are recruiting motivated experimental and/or computational postdocs! We have much brewing spanning ovarian aging, metabolic health, immune dynamics, and therapeutics🧪 hattiechunglab.bio

🔬 Decoding Silencing: How Heterochromatin Transcribes to Silence Itself! 🧬Our latest research reveals how a pioneer transcription factor-like complex PhpC/NF-Y infiltrates repressive heterochromatin, generating transcripts with hidden introns that kickstart RNAi-mediated