I'm excited to talk @ the #AMLDEPFL2024 conference today together w/ Nicolas Mathis. Join us and Amina Mollaysa Charlotte Bunne Bruno Correia Manuel S. for AI in Genomics in Garden4C from 11 am on. You'll also find us at the AI x bio after-party lu.ma/amldepfl 🧬x🤖

Coming soon! Latsis Symposium on Genome Engineering #Zurich #switzerland June 13-14. latsis-genome-editing.ethz.ch Great lineup Treutlein lab Ben Kleinstiver Raffaella Di Micco Sek Kathiresan MD Janice Chen Charles Gersbach Cejka Lab Teresa Davoli Jolanda van Leeuwen Cereseto Lab Anna Obenauf Prisca Liberali

Great news today for IHB. I warmly welcome Juergen Knoblich as new director and head of the institute. Thrilled to see the next step of our strategic evolution come to fruition and our ambitions to expand into basic biology realised. See you soon in Basel The Knoblich Lab!

If you want to do Synthetic Biology and you love lakes and mountains you have to apply! UZH’s Faculty of Medicine seeks candidates for a Professorship in Synthetic Biology/Protein Engineering (open rank). tinyurl.com/9bka23pb #AcademicJobs #SyntheticBiology #UZH

Together with the lab of Niek van Til from the UMC Amsterdam we treated vanishing white matter mice by in vivo base editing. Congrats to Desiree and Ilma to their work! cell.com/molecular-ther…

Here we demonstrate that OrthoRep can be employed to evolve genome editors - Congrats to Yanik and many thanks to all collaborators - rdcu.be/dAEnD

Impossible to do the field justice on a few pages but we (Jonathan Gootenberg Omar Abudayyeh Jeremy Walker Julia Joung Luke Koblan) tried our best to give an overview of current CRISPR technologies in Nature Reviews Molecular Cell Biology rdcu.be/dxDD9

Happy to share our recent advances in developing clinically viable in vivo #CRISPR prime editing approaches, which we just presented Keystone Symposia biorxiv.org/content/10.110…

Just shared at Keystone Symposia a new @ArcInstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts

exciting new work from Matt Durrant #hiring and Nicholas Perry & co at Arc Institute!

bridge RNAs direct modular and programmable recombination of target and donor DNA

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if you’re into transposons, CRISPR, MGEs, recombinases, or programmable biology, you’ll want to check this out:

Extremely excited to kickstart my lab TU München with Emmy Noether support from DFG public | @[email protected]. I’m very grateful to J. Keith Joung, my friends in Boston, and to A. Moretti, K.L. Laugwitz & C. Kupatt in Munich.
More details & website coming soon. #CRISPR 🫀

🚨New preprint🚨Today, we're excited to share our latest study, 'Predicting prime editing efficiency across diverse edit types and chromatin contexts with machine learning' via bioRxiv! Gerald Schwank Krauthammer Lab Bas van Steensel lab UZH Science
biorxiv.org/content/10.110…
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In our recent preprint Nicolas Mathis and collaborators developed new computational models predicting the impact of pegRNA design and local chromatin context on prime editing. Access the tools at pridict.it. Dive into the thread or read our preprint for more details:

evoCjCas9 - a new addition to the genome editing toolbox! Big congrats to Lukas Schmidheini and everyone from the Gerald Schwank and Martin Jinek lab supporting this project.

Our latest work on CRISPR-Cas systems focuses on the type III ancillary nuclease Can2. Crystallographic tour-de-force by the fantastic Kenny Jungfer with the support of Annina Sigg. Check out the preprint! biorxiv.org/content/10.110…

Just out Science Magazine
#AlphaMissense —building on #AlphaFold —based on unsupervised learning #AI , predicts impact of all 71 million human missense variants for disease-causing potential, across entire human proteome; open-source👍
science.org/doi/10.1126/sc… @jun90cheng Žiga Avsec

Protein generation with evolutionary diffusion: sequence is all you need biorxiv.org/cgi/content/sh… #bioRxiv

“A new type of vaccine… has shown in the lab setting that it can completely reverse autoimmune diseases like multiple sclerosis and type 1 diabetes—all without shutting down the rest of the immune system.”
Leveraging the liver!
see Ground Truths link in my profile
X-suppressed

Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases biorxiv.org/cgi/content/sh… #bioRxiv

The protein universe just got a lot brighter. Researchers have mined a database containing the structures of nearly every known protein go.nature.com/3sXMJz0