New preprint alert‼️ 2 postbacs, 4 years & 26 tandem repeats in the making. Super-postbac Atagun Ulas Isiktas applies systematic mutagenesis to dissect the mechanism of repeat RNA aggregation, commonly found in neuromuscular diseases. Check out his 🧵👇 Yale Neuroscience @YaleRNA Yale Kavli Institute for Neuroscience

Our latest paper on brain mosaicism is online today. Thanks to all our co-authors and other contributors. This was a great collaboration with Xiaoxu Yang, @JSchlache, @genomedan, and Joseph G. Gleeson. You can find it here rdcu.be/cLLbd .

Check out our new preview Neuron on an intriguing study by SchafferLab describing the effect of #CLP1 on mRNA 3' end diversity in #MotorNeuron models of #neurodegeneration. authors.elsevier.com/a/1exme3BtfH1X…

So proud of my first graduate student, Geneva LaForce, who privately defended her thesis the same day her Neuron paper came out!

I was so excited to see this Preview by Kinga Kamieniarz-Gdula🇺🇦#SlavaUkraini #NCNtoTlen yesterday - it really made my day! doi.org/10.1016/j.neur…

This is a wonderful program that I'm proud to be a part of, especially b/c it's how I met Dr. Derrick J. Morton x.com/GeneticsSociet…

Check out the new awesome preprint from NUIN grad student Lauren Rylaarsdam in Alicia Guemez-Gamboa about #PACS1syndrome funded by pacs1foundation and don’t miss the beautiful figures! #ProudPI

A spectrum depends on a spectrum:

‼️‼️‼️Just submitted my R01 to NINDS…

Looking forward to attending Rustbelt RNA 2022 this year at CCF! Don't miss the opportunity to attend this outstanding event and see Cleveland in the fall 🍂🍂

Happy to announce our lab is officially joining the Alzheimer's disease community with new funding support from the Cleveland Alzheimer’s Disease Research Center, as well as an ADRD R03 from The National Institute on Aging (NIA), to investigate RBPs in disease pathogenesis. Interested graduate students and postdocs, please inquire!

Next week, Dr. Joseph G. Gleeson the Chief Medical Officer of n-Lorem, discusses the role of genetics in neurology, and his optimism for n-Lorem’s future. 🔎 Check here: ow.ly/rqip50JL8Cm #mynanorarestory #nlorem #nanorare #UCSD

Excited our study is out! Led by super talent Mariah Hoye we discover new mechanisms by which Ddx3x mutations impair brain development and cause The DDX3X Foundation syndrome. We profile translation at onset of neurogenesis highlighting importance of RNA regulation 1/.doi.org/10.7554/eLife.…

Happy to share our latest work published in Journal of Biological Chemistry! We provide the first transcriptome-wide identification of RNA targets for human ADAR3 in glioblastoma cells, which we hope can be a starting ground for understanding this brain-specific RBP (1/4) jbc.org/article/S0021-…

Registration is officially OPEN! We limit the meeting to 300 participants and we typically hit this number. It is in your best interest to register early. Trainees: if you would like to be considered for an oral presentation your abstract must be submitted by Sept 10.

Really beautiful paper from the great Jack Parent @umich 'Self-organizing Single-Rosette Brain Organoids from Human Pluripotent Stem Cells'. Demonstrates a new type of human brain organoid, and models #pcdh19 female-specific epilepsy in a dish. biorxiv.org/content/10.110…

We have liftoff! Great overviews of the official launch of the iPSC Neurodegenerative Disease Initiative (iNDI). Large-scale, NIH-funded resource of genetically-engineered isogenic iPSC lines harboring neurodegeneration-related mutations. nia.nih.gov/news/new-web-p…

🔥new pre-print from the lab: nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids. 🧵on why (I think) this is an important study for everyone working on RNA fragments and/or #exRNAs. Spoiler: most RNA fragments... are not! [✂️🧬] biorxiv.org/content/10.110…

If you're the child of a scientist...