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ecDNA is hot! We encourage you to also read yesterday’s @nature paper lead by Mischel Lab Howard Chang Bing Ren and Vineet Bafna. nature.com/articles/s4158…

Check out our first preprint! Together with Richard Koche Center for Epigenetics Research (MSKCC) we show that MYCN amplicon structure is not only determined by local enhancers , as shown by Scacheri Lab Cell but that chimeric amplicons can recruit distal enhancers leading to enhancer hijacking.

A must read. Great work from Lupien Lab.

Excellent preview in Cancer Cell covering recent work on the role of extrachromosomal circular DNA in cancer, including our study in Nature Genetics with Anton Henssen et al. Thank you for the highlight, Chris Ott. cell.com/cancer-cell/pd…

Finished off with some historical sites in Jerusalem, including the western wall. Great tour with Case Comp Cancer Ctr colleagues including Scacheri Lab

To stop COVID-19, test everyone, repeatedly - Sten Linnarsson - Medium medium.com/@sten.linnarss…

Big congrats to freshly minted PhD, Andrew Morton. He just successfully defended his thesis online! Andrew Morton #DamnProud

Congrats to Corradin Lab!

How does resistance to targeted therapy develop in #lungcancer? Is it pre-existence or a de novo mechanism? Andriy Marusyk lab Moffitt Research adds evidence for a truly Darwinian, gradual development from tolerant persisters to full resistance. A THREAD nature.com/articles/s4146…

Evolutionary therapy is a new subfield in medicine (distinct from #evomed) that seeks to use our understanding of evolution to enable novel #cancer (& pathogen) therapy. Here we present the first link between #evotherapy and quantum physics. A #thread nature.com/articles/s4156…

This article is great! cen.acs.org/pharmaceutical…

Fabulous ecDNA study by Henssen and Koche! Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma | Nature Communications nature.com/articles/s4146…

Recruiting talented data scientists and molecular biologists to work on our newly funded project 👇🏼! This is our collective brainchild with ⁦Susan Bullman⁩ & ⁦CJohnstonLab⁩. Please retweet! Interested applicant please email [email protected] wmkeck.org/grant-programs…

TWEETORIAL on our new #radonc paper in The Lancet Oncology -- joint work from Cleveland Clinic Lerner Research Institute Moffitt Cancer Center CWRU School of Medicine 1/n Pan-cancer prediction of radiotherapy benefit using genomic-adjusted radiation dose (GARD): a cohort-based pooled analysis thelancet.com/journals/lanon… OncoAlert

Genome wide association studies have been used to identify genes that may be linked to opioid use disorder, but need hundreds of thousands of samples. Olivia Corradin & collaborators have developed a way to identify these genes, using a small # of samples: wi.mit.edu/news/opioids-a…

Epigenetic convergence in opioid overdose. Great to see this multi-team collaboration in print! Such a great group of people on this project. S. Akbarian, D. Mash, E. Johnson, D. Hancock, Scacheri Lab An Hoang nature.com/articles/s4138…