Very happy to present our last interdisciplinary work on heterochromatin formation, HP1 & Liquid-liquid phase separation. Great work by Maxime👏. Fantastic collaboration with the Karpen lab ! biorxiv.org/content/10.110… Below for more description 👇

We've been working on Seurat v5 for two years and are excited to share it with you soon! In a webinar w/10x Genomics and Science Magazine on 3/29, I'll introduce new methods to analyze spatial/multimodal datasets that scale to tens of millions of cells: view6.workcast.net/register?cpak=…

Dear Reviewer 1 of our manuscript, You are my hero. Sincerely, A very drained PhD student

In our new work we chart epigenome reconfiguration in human iPSC reprogramming, informing a new 'Transient Naive Treatment' (TNT) reprogramming strategy that corrects human iPSCs functionally and epigenetically. Read it here nature nature.com/articles/s4158…

Wonder if similar to PubPeer, a web portal existed where one can post the editorial rejections with reviewer’s comments …

Happy to finally share this story after such a long journey ;) Congrats to all co-authors and enjoy reading!

Melting tesseract

Very cool single-cell visualization package with support for TCR/BCR analysis and compatible with scRepertoire. Blown away by some of the viz ideas repo: github.com/pwwang/scplott… site: pwwang.github.io/scplotter/inde…

Really huge…#spatialbio…a field that keeps on giving…took me a Saturday morning (Oz time) but totally worth reading these Methods To Watch!! Baker, G. et al. Nat. Methods. doi.org/10.1038/s41592… (2024). Ma, C. et al. Nat. Methods doi.org/10.1038/s41592… (2024). Article

“New study highlights that necrosis is more common in orbital sarcoidosis than previously thought. Histopathology revealed necrotizing granulomas in 68.4% of cases, challenging the ‘non-necrotizing’ paradigm of sarcoidosis. journals.lww.com/op-rs/abstract…

#NewProfilePic

“New algorithm differentiates sarcoidosis from TB using Bm2-[CD5-CD27-] and naïve Tregs. With 90.5%/88.5% sensitivity, it offers a promising tool for tackling diagnostic challenges. #Sarcoidosis #Tuberculosis” mdpi.com/2075-4418/14/1…

“Short-term high-fat diet boosts liver ILC1 frequency, TNF-α production, and TRAIL expression via TLR9-mediated differentiation. Insights may guide strategies for liver immune regulation. #Immunology #ILC1 pubmed.ncbi.nlm.nih.gov/39551166/

“ILC1s show antitumor potential, but LysoPS-GPR34 signaling inhibits their activation. Targeting GPR34 enhances ILC1 immunity, unveiling a new checkpoint for ILC1-based cancer immunotherapy. Nature Immunology #ILC1 nature.com/articles/s4159…

“ILC1s and Tregs drive liver regeneration via Ccl2 and IL-10-mediated macrophage polarization. Targeting this axis offers new strategies to balance inflammation and enhance healing. #ILC1 onlinelibrary.wiley.com/doi/10.1002/ad…

From June '24: The transcription factor Mef2d augments type 2 immune responses during allergic lung inflammation, regulating differentiation of Th2 and ILC2 cells. buff.ly/3BdtFkS Work from aydanszeto et al. #Immunology #ILC2s Science Magazine

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. Djenet Bousbaine led the charge... nature 1/55

Activated fibroblasts drive ILC2-to-ILC1 conversion in silicosis through the Notch3-IL-18 axis, promoting fibrosis. #Fibrosis #ILC1 nature.com/articles/s4146…

🚨 Exciting Research Advancements in Sarcoidosis! 🚨 FSR is proud to award Pilot Grants to three outstanding researchers pushing the boundaries of sarcoidosis science! 🎉 📢 Read the official announcement: loom.ly/ICk26Tc #FSRPilotGrants #SarcoidosisResearch

#phdlife