Dual roles of AcrIIA1: Beatriz A. Osuna 🇲🇽 Samuel Kilcher Joe Bondy-Denomy show anti- #CRISPR protein AcrIIA1 also functions as vital autorepressor. AcrIIA1 silences strong acr promoter & binds Cas9, #allowing phages to tune Acr expression to match Cas9 levels cell.com/cell-host-micr…

Excellent read: #Phage- and #CRISPR-assisted gut microbiome engineering! Congrats Kathy N. Lam and Peter Turnbaugh. biorxiv.org/content/10.110…

When you get a draft back from your supervisor or collaborator and it is covered in comments.... Each comment does not mean, "I think your draft is bad." Each comment means, "I care about your work, and about you." #PhdChat #AcademicChatter

Interested in #geneticengineering of reporter #phages to improve bacterial diagnostics? 🤔 Our design principles are available today at Viruses MDPI! Special thanks to 1st author Susanne Meile 👏🏼, Martin J Loessner, and fellow phage engineer Samuel Kilcher. doi.org/10.3390/v12090…

Happy Postdoc Appreciation Week

Another great example of phage-antibiotic synergy, congrats! Phage-resistance often comes at a cost: incrased antibiotic susceptibility, decreased virulence, etc... #CombinationTherapy

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

Excited to share our thoughts on improving #phagetherapy through #synbio and genome engineering: authors.elsevier.com/sd/article/S09… Congrats to the 2 first authors Jonas Fernbach and Bryan Lenneman and to Martin J Loessner and Timothy Lu for a great collaboration. Artwork by Jonas Fernbach

Nothing cheers me up more than marveling at cumulative incidence curves of the Pfizer/BioNTech and Moderna vaccines 😅 #VaccinesWork

Out today👨‍🔬! Characterization of tail fibers and tailspikes from broad range E. coli #phages EP335 and EP75. Shout out to co-authors Sander Witte & Joel T. van Mierlo Micreos, Léa Zinsli, Cassie Matter & Martin J Loessner ETH Zürich, & Rafael G-Serrano. 👏 sciencedirect.com/science/articl…

How to tackle #UTIs with engineered #phage? Proud to present: biorxiv.org/cgi/content/sh…. Big shout-out to first authors Jiemin Du + Susanne Meile and co-corresponding Matthew Dunne. Thanks Lorenz Leitner, Thomas Kessler, and Martin J Loessner for all the support! ETH Zurich Balgrist University Hospital

Nice phage engineering work-around for phiKZ-like jumbo phages!

Proud to present our work on engineered #phage-based urine #diagnostics. Huge team effort led by Susanne Meile Jiemin Du Matthew Dunne + much support from Lorenz Leitner Shawna McCallin Thomas Kessler Martin J Loessner + 16 more authors! ETH Zurich Balgrist University Hospital biorxiv.org/content/10.110…

Great study covering many applications of phage engineering. Congrats! Really enjoyed seeing in vivo data comparing wildtype vs. replication-deficient phages 👍

For #phage #engineering geeks: If you are interested in modifying the genomes of virulent #Enterococcus phages, you may want to have a look at Figure 2 of our recent preprint. 🧬Cas9 is a highly efficient counter-selection tool 🧬 🧬100 % success rate🧬 biorxiv.org/content/10.110…

Help us bring engineered phage therapy to life! We are looking for a motivated research scientist to join our Micreos antimicrobial vector innovation team in Switzerland. You can find more details here: linkedin.com/jobs/view/3389… (Application through LinkedIn)

Pathogens that cause urinary tract infections #UTIs are becoming increasingly resistant to #antibiotics. ETH researchers developed a rapid test and a new therapeutic approach using bacteria-​infecting viruses known as #phages.Samuel Kilcher Matthew Dunne fal.cn/3A4Gy

What happens when you combine two #precision #antimicrobials? ➡️Enhanced #UPEC killing using #engineered #phages that release a #colicin from infected target-bacteria! ➡️See effect of this two-pronged attack in green (supplementary data from rdcu.be/dhi2D)

Urine Good Hands! Engineered phages to detect and treat #UTIs. 🙏 to Phage Directory for publishing an interesting behind-the-scenes article. 🙏Matthew Dunne Jiemin Du Susanne Meile Martin J Loessner Shawna McCallin Lorenz Leitner Thomas Kessler and team! phage.directory/capsid/urine-g…