Immunometabolism enthusiasts - Itaconate drives mtRNA-mediated interferon via inhibition of succinate dehydrogenase ⁦#cytokines2024 for more visit ⁦Shane O'Carroll⁩ poster P3-IB008

Research | Kadyrov et al. reveal that hypoxia sensing through HIF-1A regulates monocyte-derived #macrophage differentiation, determining the extent of the inflammation and #heart remodelling after injury. doi.org/10.1038/s44161… 👉 rdcu.be/dXCDr

Congrats Liam Faller and his team for these exciting findings!! P-stalk ribosomes act as master regulators of cytokine-mediated processes: Cell cell.com/cell/fulltext/…

I am very excited to share this preprint led by Cissy Yong. 🧪 This study shows how tumour sampling conditions during surgery can alter the metabolic profile of ccRCC tissues, with major research implications #Metabolomics doi.org/10.21203/rs.3.…

🚨 Super psyched this story is finally out!   Herculean effort and 3rd chef d’oeuvre in @NatCellBio by Patrizia Romani in just 5y, where we describe #mitochondrial #mechanotransduction.   nature.com/articles/s4155…   Megathread with bonuses ⬇︎⬇︎⬇︎

Finally out 🥳🎉 embopress.org/doi/epdf/10.10…

#LocationLocationLocation! 💥Our new Feature Review on the regional specialization of the immune response along #airways is out Trends in Immunology! We discuss anatomical, functional & microbiota factors controlling #innate & #adaptive #immunity! David Hoytema van Konijnenburg authors.elsevier.com/a/1jzXg5Eb0Rxn…

The older I get the more I'm beginning to understand this phenomenon....

Oh wow, this is pretty awesome 👌

A long time in the making "#KRAS G12 mutant alleles differentially control glutamine #metabolism via #FOXO1", still warm from the bakery bioRxiv Cancer Bio. Massive thanks to SUZAN! and all other amazing collaborators/friends... doi.org/10.1101/2024.1… #colorectalcancer

The single greatest misunderstanding about science by the public is that scientists solve problems; in reality, scientists are primarily concerned with creating them.

Fascinating. So is this how the first mitos prevented cells from murking themselves after they snuck inside? 😂 biorxiv.org/content/10.110…

Toxic Masculinity vs. Healthy Masculinity: How Men Are Victims Without Realizing It linkedin.com/pulse/toxic-ma… via LinkedIn

Norovirus is common, highly infectious, can cause serious and unpleasant illness, closes hospital wards especially over winter and is a risk to care homes. A norovirus vaccine, if effective, would be a major step forward. Thank you to those taking part in and running this trial

📢Last weeks #immunometabolism discoveries Bims: Biomed News 👇👇👇 biomed.news/bims-imicid/20… It's a big one this week, check it out!

"...we describe a functional genomics approach that combines genome-wide phenotypic screening in 1* murine macrophages w/transcriptional & cytokine profiling of genetic perturbations in 1* human macs to uncover regulatory circuits of inflammatory states." nature.com/articles/s4158…

Transgelin 2 guards T cell lipid metabolism and antitumour function nature.com/articles/s4158…

Pleased to share our new collaborative study (w/ the Vennetilab), led by Nneka Mbah #OpenAccess Nature Communications Check it out 👇🏼 and/or follow along for the #tweetorial (1/11) nature.com/articles/s4146…

The core skills of learning are a critical eye and an open mind. Critical thinking is refusing to accept ideas at face value. Don't believe information until it's verified. Openness is refusing to reject ideas at face value. Don't disbelieve information until it's falsified.

Very cool paper showing how regulation of MDH2 in glioblastoma stem cells controls proliferation, self-renewal, and in vivo tumour growth via aKG levels and RNA methylation cell.com/cell-metabolis…