A new genome editing system uses recombinases guided by bridge RNA which contains two independently reprogrammable loops to direct sequence-specific DNA recombination, enabling insertions, excisions, and inversions. nature.com/articles/s4158… nature.com/articles/s4158… #NBThighlight

Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress: Molecular Cell cell.com/molecular-cell…

An NAD+-dependent metabolic checkpoint regulates hematopoietic stem cell activation and aging nature.com/articles/s4358…

Online now! A safety guide for transgenic Cre drivers in metabolism dlvr.it/TC7NK5

Quantifying Muscle Regeneration: Activated Muscle Satellite Cells and New Regenerated Myofibers in Chronic and Acute Degeneration Models link.springer.com/protocol/10.10…

Congratulations, Ahmed! What a treat for the audience. 👏

Out today! We find that an epigenetic modification (6mA) to the mitochondrial genome (mtDNA) influences lifespan and the heritability of mtDNA mutations to the next generation. It implies that epigenetics determines genetic composition in future offspring. cell.com/cell-metabolis…

Overview of pathogenic mechanisms in #lupusnephritis and potential therapeutic targets. go.nature.com/434uoxJ

Dissecting the impact of differentiation stage, replicative history, and cell type composition on epigenetic clocks cell.com/stem-cell-repo…

Congratulations, Jenny! 👏

Senescent cells inhibit mouse myoblast differentiation via the SASP-lipid 15d-PGJ2 mediated modification and control of HRas elifesciences.org/articles/95229

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells | Nature Communications nature.com/articles/s4146…

Immune aging impairs muscle regeneration via macrophage-derived anti-oxidant selenoprotein P biorxiv.org/cgi/content/sh… #biorxiv_physio

Online now! Mitochondrial transplants to treat mitochondrial dysfunction dlvr.it/TCjPm9

Now Online Mechanisms of assembly and remodelling of the extracellular matrix dlvr.it/TCjr0l

Great kick-off for this year’s Smidt Heart Institute at Cedars-Sinai research seminar (SHIRS) by Executive Director Eduardo Marban, MD, PhD discussing amazing novel RNA therapeutics developed in his lab for heart disease! Cedars-Sinai Academic Medicine Cedars-Sinai Cardiology Fellowship

Eduardo Marban, MD, PhD teaching us about bioinspired non-coding RNAs at the first Smidt Heart Institute Research Seminar of the academic year! Privileged to be part of this grand adventure!

Tour the force presentation at Smidt Heart Institute at Cedars-Sinai #SHIRS by Eduardo Marban, MD, PhD Cedars-Sinai Academic Medicine Cedars-Sinai ➡️ From cells ➡️ exosomes ➡️ Novel RNA drug (TY1) ➡️ exticing new therapeutics for #HeartDisease

Achieving optical transparency in live animals with absorbing molecules | Science science.org/doi/10.1126/sc…

Online now! Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution dlvr.it/TCwKg0