Less amazing.

This may have important consequences.

Well worth reading the N&V here and the paper from Peter Westcott. Neoantigen clonal heterogeneity has an important impact on tumor immunogenicity—and therefore on tumor responsiveness to immunotherapy.

Fog rolling in off the Hudson and covering the GWB. Got a beautiful timelapse right from the window.

Surprising!

Very worth reading if you are a practicing physician 👇

Why has the proportion of cancers that could be prevented by known means not increased over 40 years? Paul Brennan Bert Hofman & I suggest it could be that exposures are ubiquitous link.springer.com/article/10.100… (a cancer-focused academic.oup.com/ije/article/40… update plus Richard Peto homage)

Housing insufficiency is one of the major challenges our country faces. It impacts every aspect of people’s social and economic lives. Major northeast cities should be aggressively focused on rectifying this (ideally by reducing barriers to building medium/high density housing)

This is toxic car culture par excellence. Speeding tickets should confer escalating financial penalties and rapidly lead to drivers license suspension with high bar for re-instatement. I cannot count how many close calls I have had with speeding cars in the city.

What digital software do postdocs and PIs use for project/grant/task management? My Evernote system is great but not scaling well over time.

LLMs with the ability to write code seem to overcome some of the limitations around numeracy and calculation ability. Impressive (if the results are correct - I didn’t check how these score on primer3)

Perhaps cars and trucks should also be discouraged from driving in the city on days with poor air quality Governor Kathy Hochul

Excellent piece from my friend Jordan Hirsch. The culture of innovation in the US is among the best in the world. Just look at the incredible and rapid progress in tech, science and medicine. We need to remember these strengths even in times of political turmoil.

Forest fires in Inwood Hill Park today and Palisades park last week. Crazy times.

Congratulations to Lindsay Caprio somnath tagore, many people in my group, and outstanding collaborators Denis Kresimir Bestak Fei Chen Lab Caris Life Sciences and many others on this paper, profiling non-small cell lung cancer brain metastases nature.com/articles/s4159…

Excited to share a new paper: tinyurl.com/49u5e6by Cell: a framework to accelerate variant classification, diagnosis & treatment of immune disorders & genetic disorders more broadly. Led by superstar, juggernaut & future dermatologist Zach Walsh