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Improving the sensitivity of in vivo CRISPR off-target detection with DISCOVER-Seq+ Roger Zou led this study with Yang Liu Oscar Reyes Gaido Max Konig, Leo Shen, Franklin Aviles-Vazquez 🇵🇷🧬🔬 Alberto Marin-Gonzalez nature.com/articles/s4159…

If you’re planning to try the exciting DISCOVERseq+ method from Roger Zou and Taekjip Ha, be sure to analyze w/ new blender2 version of the analysis pipeline. Same algorithm as blender1, but finishes in 1 minute instead of 24 hours (that’s not a typo). github.com/cornlab/blender

Excited to share our discovery of genetic susceptibility to prurigo nodularis w a measure of polygenic risk! So grateful for the incredible mentorship and collaborative spirit of Dr. Shawn Kwatra Eugene Semenov, MD Sasha Gusev jidonline.org/article/S0022-… Journal of Investigative Dermatology #dermtwitter

Excited to share that I'm joining the Hypothesis Fund as a Scientist Scout and will be supporting their efforts to fund #highrisk #highreward basic science projects! #scoutingforscience

Our work "Bursting translation on single mRNAs in live cells" is now published on Molecular Cell. sciencedirect.com/science/articl…. It is incredible when working with such an amazing group of people, Nathan Livingston, Jiwoong Kwon, JianLiu-Theoretical Cell Physics Lab, Green Lab , Taekjip Ha.

We welcome the intern class of 2023 to the MGH Dept of Medicine. We had an incredible afternoon at our annual clambake at my home. So wonderful to see the future of medicine. Inspired by their energy and optimism. It is going to be a terrific year. ❤️

Stellar thesis work by the incomparable Oscar Reyes Gaido! Amazing mechanism-driven study spanning reporter design, drug screening, and clinical translation 🤩

We end orientation for the MGH DOM Intern Class of 2023 with our white coat ceremony. A truly fantastic group of physicians. Let get started! 👏 👏 👏

Excited to share our new manuscript out in Nature Medicine nature.com/articles/s4159… We present a new polygenic score for coronary artery disease: GPS_Mult Thread 🧵⬇️ 1/12

Nothing more fun than going out with some friends and running into a group of MGH residents enjoying time together after a day of hard work MGH IM Residents

„What makes us social?“, new book by Uta Frith and @cdfrith Excellent post-on-call read – making you cherish all these special (social) moments with patients & colleagues in the hospital. #Residency #Medicine #Together

Big thx to @levfacher for inviting me to speak STAT summit. Methadone must be made available outside of the archaic clinic system that makes ppl jump through impossible hoops. We need solutions - 1 mill people are projected to die from OD by 2029. statnews.com/2023/10/20/met…

Congrats Oscar!! Amazing to see your years of hard work and dedication recognized by this well-deserved award AHA Science

Happy holidays from our residency family to yours ✨

Determination of single-molecule loading rate during mechanotransduction in cell adhesion | Science science.org/doi/10.1126/sc…

Grateful to work on this important topic with amazing mentors Pradeep Natarajan Aniruddh Patel and an all-star team Mass General Heart Broad Institute REPRIEVE Trial!

The MGH IM Residents Stanbury program attracts and trains top physician-scientists. At this year's summer retreat, MassGeneral Medicine family member Rochelle Walensky, MD, MPH shared her insights on matters relevant to her tenure as CDC Director.

1/n Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv! biorxiv.org/content/10.110…

Incredible work revealing new insights into the homology search problem, with broad implications for DNA repair and gene editing 🧬 Alberto Marin-Gonzalez Taekjip Ha. Super excited to finally see it out!

Exciting to have two of the residents working with us give talks MassGeneral Medicine Grand rounds for 2025 Resident Research Day this Thursday! Roger Zou (working w Aniruddh Patel) & Amanda Jowell (working w Michael Honigberg, MD, MPP)