🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

.Journal of General Physiology's July issue is here! hubs.la/Q03vJbzN0 The cover image highlights the voltage-gated sodium channel NaV1.8 and its targeted drug Journavx, illustrating their role in pain perception and therapeutic intervention. From Wood et al. hubs.la/Q03vJdDp0

.Journal of Experimental Medicine's latest #CME activity MSK CME is now available! ✍️💻 New content 📄: “Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein” by van Dijk et al. (hubs.la/Q03wHMHP0) Begin the CME here 👉hubs.la/Q03wHPBv0

Novel open-source diagnostic tool offers affordable, reliable pathogen detection for resource-limited settings. Read the article here life-science-alliance.org/content/8/10/e… and the press release here eurekalert.org/news-releases/…

📣 #CallForPapers 📣 Journal of General Physiology is inviting submissions on the topic of the EpIC meeting, “Emerging Research on #IonChannels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan, & Lejla Zubcevic 👉hubs.la/Q03y2lW00

📢 Now accepting applications for Journal of Experimental Medicine Early Career Travel Award, for grad students & early-career postdocs to participate in a scientific conference. This year, the award will support the attendance of #Cytokines2025 @cytokinesociety! Apply here 👉 hubs.la/Q03yQlM60

Scientist-philosopher & former Journal of Experimental Medicine editor René Dubos is the focus of a new e-book from Rockefeller University. The annotated bibliography by Carol Moberg covers his ideas on health, society, ecology, and humanity, all strikingly relevant today. More here: hubs.la/Q03zq_Qf0

In Journal of Cell Biology, Benjamin Padman et al Michael Lazarou outline a segmentation strategy for 3D FIB-SEM data from cells, termed AIVE, & identify a new type of mitochondrial contact called the mitochondrial intrusion hubs.la/Q03zwF1q0

In Journal of Experimental Medicine, Gern et al. show that the early interplay between #neutrophils & CD4 T cells is pivotal in determining #TB pathology, and that depleting neutrophils can improve outcomes even at late timepoints, which has therapeutic relevance hubs.la/Q03zwJ150

STAT1-GOF is characterized by infections & #autoimmunity. In Journal of Human Immunity, Buddingh, Schuetz et al. report overall survival after allogeneic #HSCT in an international cohort of 36 patients is 72.2%, markedly improved from an earlier report. hubs.la/Q03zBrMb0

New in Journal of Experimental Medicine: Shi et al. identify the type I BMP receptors ALK2 & ALK3 as critical mediators of T cell activation and activation-induced #CellDeath. The roles of ALK2/3 in these processes are interdependent & independent of their BMP ligands hubs.la/Q03zywvx0

Tony Harris spotlights Journal of Cell Biology study from Kim et al. (hubs.ly/Q03zMSn70), which identifies an inhibitory pathway that controls the formation of epithelial tubes during #Drosophila salivary gland #development: hubs.ly/Q03zMF4h0

New in Journal of Experimental Medicine: Fu et al. identify biallelic germline ASXL1 variants as the cause of a novel #InbornErrorOfImmunity, linking ASXL1 deficiency to epigenetic dysregulation, combined immune deficiency, chronic viral infections, & malignancy hubs.la/Q03zN5pk0

In Journal of Experimental Medicine, Metzemaekers et al. review how memory T cells fight infections & #cancer by retaining epigenetic “memories” that enable the rapid reactivation of inflammatory genes, and how such epigenetic mechanisms may fuel T cell dysfunction in disease hubs.la/Q03zNqhs0

.Journal of Cell Biology's August issue is here! hubs.la/Q03zqtYG0 The cover shows confocal #microscopy image of a #Xenopus laevis zygote in metaphase of the first embryonic #mitosis stained by immunofluorescence to visualize spindle. From Cantwell et al. hubs.la/Q03zqrGc0

.Journal of Experimental Medicine August cover (hubs.la/Q03zqFbh0) depicts the staining of proximal draining lymph nodes using multiparameter quantitative confocal imaging: OT-I T cells (pink), CD11c-expressing DCs (purple), & CD64-expressing monocytes (blue). Conlon et al hubs.la/Q03zqDJy0

New in Journal of General Physiology: Martin Heiss, Bernhard Flucher et al. unravel molecular mechanisms in a voltage-sensing domain that governs the kinetics and voltage dependence of calcium channel activation. hubs.la/Q03B7K4j0 #IonChannels

New in Journal of Experimental Medicine: Vini Tiwari, PhD & Mikael Simons review the relationship between lipid #metabolism & CNS #inflammation & how disruptions in this interplay contribute to neurological disorders hubs.la/Q03BkGPK0 #Neuroinflammation

In Journal of Experimental Medicine, Lei Yuan, Chen Dong et al. reveal that ciliated cells play an immunoregulatory role in allergic #asthma by constitutively expressing IL-17D, which limits #monocyte recruitment to inflamed lungs. hubs.la/Q03Bk_KR0 #MucosalImmunology #Inflammation #Cilia

In Journal of General Physiology, Martínez-Lázaro et al. Universidad de La Laguna show that two GRIN2B variants disrupt nanoscale coupling betwn NMDA receptors & BK channels, revealing nanodomain dysfunction as a potential mechanism contributing to GRIN2B-associated pathophysiology hubs.la/Q03Bp-lH0

💼 🎓 Check out featured positions on the RUP Career Center! Update and upload your resume today! 👉 hubs.la/Q035nSNH0