**Gut bacteria control the thermostat** Both in sepsis and in health, body temperature is modulated by the gut microbiome. New translational study from from our lab in the Blue Journal: tinyurl.com/4t4569a5 1/n

As soon as you conceptualize critical illness myopathy as a form of end-organ failure, negative trials of aggressive ICU nutrition and mobilization make more sense. It’s not caused by insufficient calories/exercise. Like giving lasix for sepsis-induced AKI. Missing the point.

Since 2021, the U.S. has had two lethal outbreaks of tuberculosis transmitted via bone graft products harvested from TB-infected cadavers. In JAMA, Debbie Dingell and I explain the regulatory gap that's allowed this to happen, and how to fix it. jamanetwork.com/journals/jama/…

If you're at ATS, come check our our lab's presentations!

Congratulations Jeffrey L. Curtis on your Distinguished Achievement Award this year. Proud to call you a friend and colleague. Michigan Medicine Pulmonary & Critical Care 🫁 U-M Medical School Research #ATS2024

Most viewed in the last 7 days from JAMA Internal Medicine: Study compares the administration of piperacillin-tazobactam compared with cefepime among patients with suspected sepsis and no clear indication for antianaerobic coverage. ja.ma/4bmYel6

Not to oversell it... but Jenn will change the way you think about pneumonia pathogenesis.

#ATS2024

What if there was an antibiotic that doesn't disrupt the gut microbiome? There is now. A discovery published nature today nature.com/articles/s4158… Paul Hergenrother and colleagues University of Illinois justsaysinmice

Viewpoint from Robert Dickson and Rep. Debbie Dingell discusses the death of a patient caused by unregulated biological products and efforts to encourage federal government oversight of such products. ja.ma/3KjTBwi

🌟 Meet Dr. Chanderraj, our PITB #highlight for June 2024, & learn about his research and interesting hobby! Check out his work on mortality in #sepsis in patients treated empirically with #cefepime vs. piperacillin-tazobactam ⏬️

Great study from the group of Robert Dickson 👇👇showing a relationship between the microbiome and chronic rejection after lung transplantation. I’m starting to think there might actually be something to this whole microbiome thing 😂

Critical Care Reviews NEJM Evidence CIHR CFI / FCI Accelerating Clinical Trials Canada Michelle Kho, PT, PhD Heather O'Grady CCCTG Canadian Critical Care Society McMaster School of Rehabilitation Science McMaster Health Sciences McMaster University The Research Institute of St. Joe's Hamilton Critically ill muscle isn’t programmed for exercise, it’s programmed to support immune defences and it isn’t in its usual phenotype, exercise doesn’t have the usual effect - deliberate muscle catabolism. Hopefully Zudin can lead us to the answers!

Jennifer Baker (Jennifer Baker), PhD candidate Dept of Microbiology & Immunology @ the Univ of MI, studies the relationship between acute lung injury & the microbiome in the labs of Robert Dickson and Gary Huffnagle, PhD. michmed.org/Ane5m #GoBlueScience

My all-time favorite Game of Thrones intro.

Wordle 1,192 1/6 🟩🟩🟩🟩🟩

I've seen claims online that tardigrades can live for 30 years without food or water. A Nat Geo article says this, without attribution. My initial reaction was that this must be an estimate. Why would anyone wait 30 years to figure this out? But Japanese scientists actually did.

Here’s a timeline of my career Orange=grants submitted Green=grants funded Lessons learned? -persistence pays -scientist=professional writer -grant writing makes the science better -scientist=entrepreneur. Not every “invention” is a hit (learned this from Shark Tank)

In contrast, in college football's top division, 134 teams play zero exhibition games, 12 regular season games, and compete for 102 trophies they made up themselves, not counting the conference, bowl, and playoff trophies. (2/7)