Our newest paper on sugar display on DNA scaffolds and hyper-glycosylated DNA published in ChemEurJ: Chemistry - A European Journal doi.org/10.1002/chem.2… IOCB Prague Akademie věd ČR Faculty of Science of Charles University

Our Pick of the Week, out #OpenAccess in ChemEurJ: Chemistry - A European Journal by Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 & team at IOCB Prague and Akademie věd ČR: Glyco-DNA: Enzymatic Synthesis of Base-Modified and Hypermodified DNA Displaying up to Four Different Monosaccharide Units in the Major Groove 🧬🍬 ow.ly/FHEI50SSSOP

Our newest paper on reactive modification of DNA for crosslinking and bioconjugation with Trp-containing peptides and proteins published in ChemEurJ: Chemistry - A European Journal IOCB Prague Akademie věd ČR Faculty of Science of Charles University doi.org/10.1002/chem.2…

A new PhD is among us! Congratulations to Bianca Maria Mititelu on her successful thesis defense and thanks for all your hard work and time spent in our lab. We will miss you! Stay tuned for Bianca's paper about a novel RNA cap... IOCB Prague Charles University RNA4T: RNA for therapy

Differential effects of 40S ribosome recycling factors on reinitiation at regulatory uORFs in GCN4 mRNA are not dictated by their roles in bulk 40S recycling nature.com/articles/s4200…

Yesterday,#RNAClub2024 took place at CEITEC,featuring excellent talks, inspiring guests, engaging poster presentations,and fruitful networking opportunities!🧬 Many thanks to everyone who participated and contributed to the valuable discussions, as well as to our sponsors👏

Today, we are excited to continue our work in #RNA with the launch of a new project – RNA4T: RNA for Therapy. We look forward to the challenges and collaborations ahead! 🔬 #CEITECScience Read more about RNA4T here ➡️ uochb.cz/en/rna4t

New paper by the Stefl group: Linhartova, K. et al. Sequence and structural determinants of RNAPII CTD phase-separation and phosphorylation by CDK7. Nat Commun 15, 9163 (2024). rdcu.be/dXZmH

Mycobacterial HelD connects RNA polymerase recycling with transcription initiation doi.org/10.1038/s41467…

Our newest paper on bacteriophage-related epigenetic pyrimidine nucleotides and their influence on transcription with T7 RNA polymerase published in Communications Chemistry in Collection Nucleic Acid Chemistry: doi.org/10.1038/s42004… IOCB Prague Faculty of Science of Charles University Akademie věd ČR

Ambra Spampinato has successfully defended her PhD thesis entitled: Modified Nucleotides and DNA Bearing reactive Groups for Bioconjugation and Cross-linking with Proteins. PhD No. 45 from our group. Congratulations! IOCB Prague Faculty of Science of Charles University

#research Enzymatic synthesis of reactive RNA probes containing squaramate-linked cytidine or adenosine for bioconjugations and cross-linking with lysine-containing peptides and proteins (Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪) - Communications Chemistry: nature.com/articles/s4200… IOCB Prague Faculty of Science of Charles University Czech Academy of Sciences

Our new paper (with P. Rezacova group) on the use of environment-sensitive fluorescent nucleotide in DNA probes for identification of effectors of TFs and studying conformational changes of protein-DNA complexes published in RSC Chemical Biology : doi.org/10.1039/D4CB00… IOCB Prague

Our newest paper on enzymatic synthesis of hypermodified zwitterionic DNA displaying 4 different cationic groups just published in @NAR_Open - see: doi.org/10.1093/nar/gk… IOCB Prague Akademie věd ČR Faculty of Science of Charles University

Our newest paper on enzymatic synthesis of hypermodified DNA bearing functional groups mimicking amino acid side chains in enzyme active sites just published in ChemEurJ: Chemistry - A European Journal . doi.org/10.1002/chem.2… IOCB Prague VŠCHT / UCT Prague Faculty of Science of Charles University Akademie věd ČR

Our newest paper on enzymatic incorporation of 2-substituted adenine nucleotides into RNA and their use for RNA labeling has been published in @chembiochem : doi.org/10.1002/cbic.2… IOCB Prague Akademie věd ČR Faculty of Science of Charles University

Polymerase synthesis of base-modified DNA scaled-up to milligram quantities suitable for NMR structure studies. Check our newest work published in ChemistryEur doi.org/10.1002/ceur.2… IOCB Prague Faculty of Science of Charles University Akademie věd ČR

Super-Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation - new paper in collaboration with C. Cardoso group published in Adv. Sci. : doi.org/10.1002/advs.2… IOCB Prague Faculty of Science of Charles University Akademie věd ČR

Our newest paper Versatile Enzymatic Approach for Truncation, Labeling, and Mutation of Nucleobase-Modified Aptamers Demonstrated on Indole-Modified β-Conglutin Aptamer published in ChemBioChem : doi.org/10.1002/cbic.2… IOCB Prague Akademie věd ČR Faculty of Science of Charles University

Our new paper on Enzymatic synthesis of base-modified RNA and influence of the modifications on stability, translation, and CRISPR-Cas9 cleavage - published in ACS Chem. Biol. (ACS Publications Bio & Med Chem Content ): doi.org/10.1021/acsche… . IOCB Prague Faculty of Science of Charles University Akademie věd ČR