Very happy to share our #singlecell #multiomics analysis of #MDS patients and clinical response to #HMA in Cancer Research Communications Manel Esteller Check it out!✨ aacrjournals.org/cancerrescommu…

Excited to share my first first-author paper: T-FINDER! 🎉 We've crafted a super-sensitive TCR signaling reporter with an innovative antigen processing system. Explore how we identify unknown peptide:HLA ligands - Check it out here on Science Advances: doi.org/10.1126/sciadv…

Really glad to see our work published in nature Communications Biology: nature.com/articles/s4200…. This analysis of 39 fragment screening experiments sets the scene for our future work on function prediction for ligand sites across the Protein Data Bank. Geoff Barton Barton Group Stuart MacGowan Callum Ives

Enjoying the ISCO’24 conference at Barcelona and presenting our work in Alcoholic Liver Disease🧬

📢Our lab at the Josep Carreras Leukaemia Research Institute (IJC) is looking for candidates for the competitive PhD INPhINIT incoming fellowship from La Caixa Foundation. We work on the application of #singlecell genomics and ML to improve cell-based immunotherapy in Myeloma and others B-cell neoplasms. Plz RT!🔁

Our multimodal model to combine TCR sequences with scRNA-seq is finally out. The most interesting part for me was observing a clear case where the combination of TCR sequence and cell state (RNA) preserved both clonotype and cell type information, leading to a more holistic cell

Brilliant ✨ #YoungResearchers Seminar yesterday with Aina Rill, from Elisabetta Mereu 🇺🇦’s lab! We have learnt more about her project "Integrative #SingleCell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B-cell neoplasias". Great work! 👏

STAMP is OUT! Sequencing-free #singlecell RNA and Protein profiling. Game-changing approach for scalable and cost-efficient analysis of single cells. The future starts today! Amazing ⁦Luciano Martelotto 🛠🧬💻🇦🇺⁩ ⁦Dr. Jasmine Plummer 👩🏻‍🔬🧬🇨🇦🇺🇸⁩ biorxiv.org/content/10.110…

🚀 New research alert! Dive into the single-cell multi-omics of CD19-CAR+ and CAR- T cells! A promising step in #CARTcell therapy for better outcomes! Led by Mercedes Guerrero, Aina Rill & trincadojl from Menendez Lab and my lab! Enjoy! cell.com/action/showPdf…

Published today Nature Biotechnology: @CarlHJune and I reveal how CAR T cells are finally tackling solid tumors! Penn Postdoctoral Association Penn Medicine MD nature.com/articles/s4158…

So i'm very happy to say that my very talented honours student has reimplemented the entire trajectory workflow in R, intersecting with Nick Borcherding's scRepetoire! Code is now live github.com/tuonglab/dande… but lacking vignette; will be up shortly!)

Very honored to have received one of the Molecular Oncology Poster Session Awards last week from #IJCSymposium “Updates on Genetics and Epigenetics of Haematological Malignancies: From Knowledge to Applications” at Josep Carreras Leukaemia Research Institute (IJC) ✨

🏆Congratulations to Aina Rill for winning a Molecular Oncology prize at the 2024 Josep Carreras Leukaemia Research Institute (IJC) Symposium, with her poster "Integrative single-cell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B-cell neoplasias"👏

It took 3 years, 4 rounds of reviews, 96 VISIUM samples, 10 cancer types, and 1 clinical trial, but it's finally out: The spatial landscape of Cancer Hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity Here's what's new 👇 cell.com/cell-reports/f…

We have now written up a preprint on this! biorxiv.org/content/10.110… Nick Borcherding