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I hate python I hate python3 I hate pip3 I hate pip I hate venv Why can't they just come up with a normal version and package manager for god's sake. This is ridiculous.

The Impact of Metagenomics on Biocatalysis dlvr.it/T4DFj4

Whoah, cucumber too? Is it someone’s birthday?

Now online: Article by Yunfang Yang, Marc Garcia-Borràs, Xiongyi Huang-JHU Biocatalysis & co-authors Engineering non-haem iron enzymes for enantioselective C(sp3)–F bond formation via radical fluorine transfer nature.com/articles/s4416… ($)

Happy to announce our latest publication on #enzymedesign, in collaboration with Thompson Lab - UC Merced! Check it out in J. Am. Chem. Soc.: Design of Efficient Artificial Enzymes Using Crystallographically Enhanced Conformational Sampling pubs.acs.org/doi/full/10.10…

Enhancing PET Degrading Enzymes: A Combinatory Approach dlvr.it/T5CVQX

🚨paper alert🚨 #Epistasis makes combining mutations unpredictable.🤷 This complicates #enzymedesign and predicting the effect of mutations.⁉️ Through in-depth evolutionary analysis, we recently uncovered an underappreciated mechanism for epistasis.🧬♻️🔍 nature.com/articles/s4192…

Have you ever wondered if it is worth it to engineer remote mutations out of an artificial enzyme? Well, we did. Check out our latest contribution to Faraday Discussions on their #biocatalysis special issue. Some highlights are below! pubs.rsc.org/en/Content/Art…

Boron catalysis in a designer enzyme (nature): nature.com/articles/s4158… (Roelfes Group (find us as @roelfesgroup on BS), Lars Longwitz, Reuben B. Leveson-Gower).

A PhD position is available to join my group in TU Delft titled "Evolving Enzymes for New Chemistry" in the Department of Biotechnology Biocatalysis section Biocatalysis@TUDelft Applications open until 26-07-2024. Retweets much appreciated! tudelft.nl/over-tu-delft/…

Fantastic science on show at #ECB2024 in Rotterdam, and happy to discuss some of my previous research as a poster pitch Roelfes Group (find us as @roelfesgroup on BS) @StratinghInst. Great also to have a strong presence from TU Delft Biotechnology, especially the Biocatalysis section! Biocatalysis@TUDelft

We're very happy to share our latest paper, which is by Judith and the groups of Marc Garcia-Borràs and Sarel Fleishman! We used AlphaFold2 and Funclib to design a targeted library of UPO variants, from which we then prepared oxyfunctionalised terpenes. Read here: biorxiv.org/content/10.110…

Evolutionary Specialization of a Promiscuous Designer Enzyme; Reuben B. Leveson-Gower L. Tiessler-Sala, H. J. Rozeboom, A. W. H. Thunnissen Jean-Didier Maréchal & G. Roelfes #Biocatalysis #DesignerEnzymes #DirectedEvolution #XrayCrystallography doi.org/10.1021/acscat…