🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Glad to see this finally published! 😊 pnas.org/doi/10.1073/pn…

Astrocytes remember inflammation dlvr.it/T72ZSq

In this manuscript we report the discovery that mitochondria contacts with microtubules are hotspots of tubulin acetylation, which occurs through the recruitment of the tubulin acetyltransferase 1 (ATAT1) to mitochondria outer membranes by MFN2.

Awesome work with ZoherGueroui @zgueroui.bsky.social Useful approach to trap and release #lipiddroplets on demand! Great potential for trapping lipid droplet subpopulations based on their proteome.

Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS: nature.com/articles/s4159…

Happy Thursday! As the end of the week approaches, check out this publication investigating annexin A11 aggregation in FTLD-TDP type C and related neurodegenerative proteinopathies. doi.org/10.1007/s00401… @PennBiNDLab, David Irwin, Silvia Porta, Vivianna Van Deerlin, Eddie Lee

Super excited to announce our latest work in Molecular Neurodegeneration! We generated new anti-acetylated-tau-K174 antibodies that effectively mitigate neurobehavioral impairments and reduce pathology in PS19 mice— alone and in conjunction with TBI. (1/5) Details here: bit.ly/4bbKokA

"Why Brain Organoids Are Not Conscious Yet" Read the Perspective by Kenneth Kosik (@Kosik NeuroSci Lab) in Patterns, a Cell Press journal: cell.com/patterns/fullt…

Ube3a unsilencer for the potential treatment of Angelman syndrome: nature.com/articles/s4146…

Excited to share our new paper: mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes Project led by ⁦Kun Leng⁩ & ⁦Brendan Rooney⁩. jneuroinflammation.biomedcentral.com/articles/10.11…

Tauists! Consider submitting your manuscripts to the upcoming special issue in Alzheimer's & Dementia Journals featuring new opportunities and progress for the therapeutic targeting of #tauopathy. Deadline Oct. 1, 2024. Guest edited by myself and Dr. James Rowe: alz-journals.onlinelibrary.wiley.com/journal/155252…

Lysosomes drive the piecemeal removal of mitochondrial inner membrane | Nature nature.com/articles/s4158…

Online Now: Large-scale map of RNA-binding protein interactomes across the mRNA life cycle dlvr.it/TDS2Qd

The genome can capture foreign DNA. AAV vector integration was the most common editing event at each DNA break site we examined, far surpassing Cas9-generated indels. PolyA and promoter elements, which are routinely found in recombinant AAV vectors, have the potential to

Ribosomes hibernate on mitochondria during cellular stress: nature.com/articles/s4146…

Our latest paper on neuronal resilience. The apoptotic pathway is activated as a transient pulse in neurons even with continuous apoptotic stimulus. Neurons prepare for survival even when they activate apoptotic signaling. Congrats Keeley and others!! nature.com/articles/s4141…

Preprint alert! Led by Shannon Rhoads, we used 🌈🔬 to elucidate the #organelle signatures of #neurons and #astrocytes at baseline and in response to neurodegenerative-disease associated stressors. See Shannon's awesome tweetorial below! biorxiv.org/content/10.110…

Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes: cell.com/neuron/fulltex…

Having started my career in basic neuroscience research, I have always understood Alzheimer disease to mean the pathophysiology associated with amyloid plaques and tau tangles. As a clinician, I appreciate that the relationship between Alzheimer disease and cognitive impairment

The Celeste Karch demonstrate that MAPT mRNA and tau protein are expressed in microglia in human brains and in hiPSC-derived #microglia like cells. 🧠 💡Learn more in their new molecularpsychiatry study: go.nature.com/447xVwS