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Immune checkpoint inhibitors are approved for the 1st-line treatment of metastatic MSI-H or dMMR colorectal cancer. In this article in Annals of Oncology, Dr. Toky Ratovomanana and coll. investigated DNA/RNA predictors using 2 prospective independent cohorts annalsofoncology.org/article/S0923-…

Thrilled to share our article freshly published in The Lancet Gastroenterology & Hepatology regarding the new immune strategies in #PancreaticCancer ! sciencedirect.com/science/articl… Great teamwork with medical oncologists, surgeon, pathologist and basic researchers. Rémy Nicolle Matthieu Delaye

This month’s Lancet Gastro cover highlights our review 🔥 Let’s better understand this disease to improve our care. #PancreaticCancer

Validating in a randomized setting that the transcriptome can predict sensitivity to Gemcitabine in Pancreatic Adenocarcinoma Advocating for clinical RNAseq An ancillary Study of the PRODIGE-24/CCTG PA6 Trial ascopubs.org/doi/10.1200/JC…

Very happy to share our collective work validating the use of predictive RNA based signature to predict gemcitabine sensitivity in a randomised trial. Similar efficacy to FFX in selected patients with much less side effect in the adjuvant setting. ascopubs.org/doi/10.1200/JC…

Huge 👏Rémy Nicolle et al Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC… ✅GemPred a FFPE transcriptomic sig ➡️validated in PRODIGE24/CCTG PA6 adj gem vs mFFX ➡️predictive of gem DFS &cancer specific survival(CSS) ➡️GemPred+ pts receiving gem CSS=68.4mths! 🔥Imp in future trials ESMO - Eur. Oncology

This is fascinating. Drug-specific resistance through an (epi)genetic-encoded landscape of possible attainable phenotypes. An amazing framework for clinical combinations

A recent review on the the immunological landscape in pancreatic ductal adenocarcinoma looks at means to overcome resistance to immunotherapy in this setting thelancet.com/journals/langa… #GITwitter #PancSM #PancreaticCancer

Happy to share our latest preprint led by Omar S.M. El Nahhas 🌟: A manual for our deep learning pipeline for pathology image analysis, tried and tested in dozens of projects, fully open source. TU Dresden @nct_hd Nationales Centrum für Tumorerkrankungen Dresden Hochschulmedizin_TUD arxiv.org/abs/2312.10944

Not all ductal cells are identical in the pancreas 💡Differ by organoid-forming, differentiation capacity and localization 🎉 Favorite '24 pancreas study so far A must read

#ArtificialIntelligence and #PancreaticCancer pathology.jhu.edu/pancreas/news/…

⚡️🔬📣Excited to share our two new Nature Medicine articles, we develop computational pathology foundation models, 1. UNI, a self-supervised computational pathology model trained on 100 million pathology images from 100k+ slides. 2. CONCH, a vision-language model for

Out today from the Stegle, Theis, and Moore labs! SpatialData is a user-friendly computational framework for exploring, analyzing, annotating, aligning and storing spatial omics data that can seamlessly handle large multimodal datasets. nature.com/articles/s4159…

Absolutely thrilled to present our new Invasion and Metastasis Lab paper published in Science Advances using #proteomics to dissect the temporal landscape of #ECM #proteins in #pancreaticcancer mouse models🐁 science.org/doi/epdf/10.11… Tweetorial below 👇1/13

Agreed, it's amazing