Looking for a Research Associate in the protein biochem space in the Seattle area. Position with great potential biospace.com/job/2337469/re…

A Perspective on the new paper in Science Magazine by Brian Shoichet and friends. Bottom line? There are no short cuts to finding effective anti-viral medicines for Covid. Ingo Hartung science.sciencemag.org/content/373/65…

Read my 16 August membrane protein/SBDD newsletter: "Lipids getting in and out of the way" getrevue.co/profile/reduce…

Read my 30 August membrane protein/SBDD newsletter: Membrane protein structures bearing more membrane protein structures getrevue.co/profile/reduce…

How often should I send out a membrane protein / SBDD newsletter?

Read my 13 Sept membrane protein/SBDD newsletter "Everything seems connected" getrevue.co/profile/reduce…

Ready my 20 Sept newsletter: "Membrane protein structures key to new drugs” getrevue.co/profile/reduce…

Read my Oct 11 newsletter: “The assembly makes the function” getrevue.co/profile/reduce…

Read my Nov 1st newsletter: “Unleashing the power of AI & video gaming on membrane protein structures” getrevue.co/profile/reduce…

Read my Nov 8 newsletter “The secret lives of membrane proteins — as never seen before” getrevue.co/profile/reduce…

#Omicron mutation P132H in SARS-CoV-2 main protease (nsp5 = Mpro = 3CLpro) ~22Å away from active site but on same loop; expecting minimal impact on #Pfizer drug PF-07321332 (nirmatrelvir, #paxlovid active ingredient) inhibition; data?

Viruses make odd #MembraneProteins #HepatitisC biorxiv.org/content/10.110…

Read my Jan 10 newsletter “From 3D structure to new drugs” getrevue.co/profile/reduce…

Fortunately no further mutations in Mpro of PANGO lineages BA.2 & BA.3. All with same P3395H (ORF1a) mutation. Same (=none at all?) impact on #paxlovid effectiveness Anybody seen enzyme inhibition data?

Read my Feb 2 newsletter : “Transmembrane impacting drug molecules” getrevue.co/profile/reduce… Seeing signalling and transport clearly and with a little help from AlphaFold

Read my March 28 Newsletter : “Membrane proteins sculpting membranes and lipid droplets” getrevue.co/profile/reduce…

Read my April 25 newsletter: “cryoEM dominating membrane protein structural biology” getrevue.co/profile/reduce…

Structural transitions along the catalytic cycle of the bacterial MurJ flippase visualized by molecular morphing (PDB codes: 6NC6, 6NC7, 6NC8 and 6NC9) #scivis #sciart #molecularart #UCSFChimeraX

Looking for a Drug Discovery Data Architect to join Omeros (Seattle, WA). Would love talking to you - especially if you can cross over life science / data. ow.ly/m8Xt50JcwHu

Was a nice run. Possibly last tweet #MyTwitterAnniversary