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Great to see this bioRxiv uncovering how factors found in the tumor microenvironment change the T cell surface #proteome. Awesome work led by Jamie Byrnes in collaboration with Marson Lab and Alan Ashworth, along with others! #UCSF biorxiv.org/content/10.110…

✨ One of our most read articles in the last 12 months! ✨ Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1 by Cotton, Nguyen, Gramespacher, Ian Seiple & Jim Wells  🔓 #OpenAccess fal.cn/3kHsB

Interested in MHC-peptide complexes or #senescence? In our recent work, Nick Rettko developed antibodies and scFab CAR constructs to p16 MHC-peptide complexes, which could provide a new way to identify and target senescent cells. More MHC work to come! pubs.acs.org/doi/abs/10.102…

I'm excited to share our new cell surface N-terminomics technology to shed light on extracellular proteolysis ACS Central Science (pubs.acs.org/doi/10.1021/ac…)! Using #glycotime, @k_r_schaefer developed a glycan-tethered peptide ligase to capture proteolytic sites on living cells.

Great collaboration from ⁦Nick Rettko⁩ and ⁦Lauren Stopfer, PhD⁩ from Forest White's lab where we show MEKi can increase presentation of pMHC's derived from tumor-associated antigens, which can be targeted with BiTEs for enhanced cytotoxicity in melanoma! pnas.org/doi/10.1073/pn…

So proud to see my former postdoc Jie Zhou stepping into her own! 🌟 Watching her launch a new lab after our remarkable journey together at UCSF is very rewarding. Wishing her all the success, and eagerly anticipating our future collaborations!

We’re #hiring! We are looking for talented individuals to be a part of our research efforts. We use proteomics, functional genomics, and antibody engineering to study and control #microglia reactive states in #alzheimersdisease. Apply today! aprecruit.ucsf.edu/JPF04728

I’m delighted to share a new photocatalyst-based proximity labeling (Multi-map) that identifies protein interactions across multiple proximity labeling probes spearheaded by Zhi lindsey Lin and wells lab team including @k_r_schaefer and QBI collaborators.

Excited to the see the diversity of and emerging successes for extracellular protein degradation (eTPD) to pair with the established successes of intracellular protein degradation (iTPD). Kaan Kumru and I are thrilled to share this review! ...no protein is safe!

Congratulations to Matt McHenry & the entire team, including collaborators Jim Wells Gygi Lab John R. Engen Thomas Wales, on the discovery of a covalent inhibitor of BAX, a blueprint for developing drugs to protect cells from unwanted cell death. nature.com/articles/s4158…

Thrilled to see this work out! A project I worked on in Jim’s lab Jim Wells in partnership with the very talented graduate student Sophie Kong. nature.com/articles/s4158…