How do cancer cells remember that they’re cancer cells after undergoing division? Research from The Roberts Lab at St. Jude shows how members of the SWI/SNF chromatin remodeling complex act as a “bookmark” for cell identity. bit.ly/426FiBI nature

Now Online SWI/SNF chromatin remodellers persist through mitosis dlvr.it/Sq9sXR

Excited to finally share that I will be joining the Mustafa [email protected] and Gerd Blobel Labs for my BBCB Graduate Group thesis. Looking forward to study genomic architecture at the single molecule level!

.HudsonAlpha gave me my first glimpse of science as a career in 2017, so I was thrilled to be able to come back to celebrate 15 years of the Institute and to see old friends!

Time flies when you’re having fun! Hard to believe it’s been 10 years since I started my scientific career as a Biotrain intern at HudsonAlpha. Glad I could make it to Huntsville for the alumni reunion today and visit with my former Biotrain/Roberts lab colleague Raymond Carter

Congratulations to our SUIP summer student Kareena Shankta on an amazing poster today. This summer she learned single-molecule tracking & embryo injection to generate exciting data on chromatin mobility in development. Great mentorship by Apratim (Appy) &instruction by Raymond Carter

Fun labor day celebration with the lab and partners!

The Roberts Lab found a way to potentially turn back the clock on some cancer cells to offer a new treatment paradigm. Removing a 2nd protein from cancer cells already experiencing tumor suppressor loss may return those cells back to a more normal state. bit.ly/3ITapcT

So proud to have been a part of this story!

Check out this stunning work led by Sandi and Hong Yue now out in nature uncovering the role of DCAF5 in cancer! Gorgeous mechanistic dTAG data, including validation in mice. Honored to be part of this amazing collaborative team. Congrats, all!! 🧵👇

Nature research paper: Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF go.nature.com/4aA7Rfz

Scientists uncover potential path to treating deadly childhood tumor statnews.com/2024/04/01/chi…

1/n) Excited to share our new preprint: Using high-res live embryo imaging we show that transcription factor hubs are localized to new genes when specific DNA binding is perturbed. Hub interaction kinetics at these new sites determine factor occupancy: biorxiv.org/content/10.110…

Big congratulations to our labs 5 (!!) new PhD candidates, all of whom passed their qualifying exams over the last month. Very proud of Alexandria O. Adigun, Sena Sarıkaya, Raymond Carter, @_KyleFerguson_ & Manya Kapoor, each of whom have very distinct & creative thesis proposals.

Thrilled to be appointed to the UPenn Dept of Biochem & Biophys Structural Biology and Molecular Biophysics Training Grant! This funding will be invaluable for my research and career development.

Chromatin remodellers as therapeutic targets bit.ly/3S7moIL This review by Hayden Malone & Charles Roberts The Roberts Lab discusses progress in therapeutically targeting chromatin remodellers, with a focus on SWI/SNF complexes, which are often dysregulated in cancer

🚨 New Research Alert! 🚨 Excited to share our latest paper on PHF6's role in linking H3K14 acetylation, #SWISNF, and #RNApolymerase complexes. Now live in Nature Communications! 🎉 Big congrats to the first author, Dr. Priya Mittal, and all co-authors! 👏 nature.com/articles/s4146…

(1/n) From Viraat Goel @Irate_Physicist et al. collab w blobellab Leonid Mirny biorxiv.org/content/10.110… RCMC at the M-to-G1 transition reveals strong microcompartments between CREs (E,P) in mitosis, that weaken upon G1 entry Sims reveal chromosome compaction as key regulator

The Roberts Lab is looking for highly motivated, intellectually engaged candidates with an interest in #ChromatinBiology to fill a Researcher position. Check out the link below and feel free to reach out with any inquiries! talent.stjude.org/careers/jobs/J…

Congratulations to Gerd Blobel (CHOP Research/ Penn Medicine/ Penn Epigenetics) on his election to the National Academy of Medicine! Learn more about Dr. Blobel & his research here➡️ blobellab.squarespace.com #PSOMatNAM National Academy of Medicine