Our paper now acepted in Nature!

Nature research paper: Cryo-EM structure of the human cardiac myosin filament go.nature.com/49lQSOf

Nature research paper: Structure of the native myosin filament in the relaxed cardiac sarcomere go.nature.com/49hBYIy

Our #human #cardiac thick filament structure paper is highlighted in nature News and Views. It is a significant breakthrough, answering questions of #heart #muscle structure, #physiology, and #disease that have remained a mystery for 60 years. shorturl.at/BDI46

The University of Massachusetts Padron-Craig lab #Cryo-EM paper (Dutta et al.) back-to-back with Raunser lab #Cryo-ET (Tamborrini et al.): an example of complementarity and reproducibility of these #EM techniques. Dutta et al shorturl.at/mwU16 Tamborrini et al shorturl.at/itvB6

Thick filaments help the heart to beat. Peter Knight Understanding Life in Molecular Detail @ScienceLeeds discusses structural evidence that provides new insights about these myosin-containing filaments. go.nature.com/49klsru

PDB 8G4L atomic structure of #human #cardiac #myosin thick filament released: it resolves past uncertainties & integrates previous data on cardiac #muscle structure & function. shorturl.at/egiEG shorturl.at/hAP14 shorturl.at/bept8

Thick filaments help the heart to beat. Peter Knight Understanding Life in Molecular Detail @ScienceLeeds discusses structural evidence that provides new insights about these myosin-containing filaments. go.nature.com/3tZAvGP

The University of Massachusetts Chan Padron-Craig lab PDB 8G4L atomic structure was achieved at the University of Massachusetts Chan Cryo-EM Core, superbly staffed and equipped (Thermo Fisher Titan Krios, Talos-Arctica, Glacios), providing excellent hands-on training. shorturl.at/wJ124 shorturl.at/DPT39

Excited to have played a small part in this amazing study in nature by Drs. Dutta, Nguyen, Padron, and Craig from UMass Chan Medical School, UMassRadiology. Thank you to the patients and families who made it possible. Let's hope the research accelerates therapies. uknow.uky.edu/research/uk-re…

Two papers in nature describe the structure and conformation of myosin in the cardiac thick filaments and how it interacts with other proteins, such as titin and cMyBP-C, in mammalian hearts ($): doi.org/10.1038/s41569… Davide Tamborrini, @intein, Raúl Padrón #ResearchHighlight

Really proud to share our last preprint on Omecamtiv and Mavacamten, two modulators of cardiac myosin. Years in the making. Very happy to work with the team, especially Anne, Carlos, Daniel & Stéphane on this paper. biorxiv.org/content/10.110…

“While science can be a challenge… All that pales in comparison to the thrill of the questions to be asked, of seeing them answered one day.” Prof. Eva Nogales’ acceptance speech at 2023 #ShawPrize Award Presentation Ceremony. youtu.be/PANxrHC-wfw The Nogales Lab UC Berkeley

This week in Nature: Beat generation - molecular structure of the myosin filaments that power the heart Browse the full issue: nature.com/nature/volumes…

Learn about UMass Chan Medical School’s newest Nobel Laureate, Victor R. Ambros, PhD: direc.to/mmB4 This morning, Dr. Ambros learned that he is the co-recipient of the 2024 The Nobel Prize in Physiology or Medicine for the discovery of microRNA. #NobelPrize UMass Molecular Medicine

How can you not smile at this photo of one Nobel Laureate from UMass Chan Medical School, Craig C. Mello, PhD, taking a selfie with another, Victor R. Ambros, PhD? Dr. Ambros was named the co-recipient of the 2024 Nobel Prize in Medicine or Physiology on Oct. 7. #NobelPrize The Nobel Prize University of Massachusetts

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