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A key point in Project BIOCHEM is to utilize all the functions of open mixed cultures to convert waste into chemicals. @AlberteRegueira showed how to model these fermentations at #FOSBE2019 IFAC Biosystems & Bioprocesses - T.C 8.4

We just had our project meeting at #TUHH facilities. The take home message is clear: engineer altogether the substrate, the microbial community and the downstream to obtain bioproducts from residual streams. CRETUS VTT #TUHH

We will be showing Project BIOCHEM latest results on the model-assisted development of biorefineries in the Symposium “Challenges of the biological conversion of residues into platform chemicals”, tbh in Santiago de Compostela on 28 May 2020 Abstract deadline: March 13

Producing propionic acid and other VFAs from residues is often limited by product inhibition. Biochem members Ludwig Selder, An-Ping Zeng and co from TU Hamburg show how to boost productivity by in-situ product removal with electrodialysis membranes. link.springer.com/article/10.100…

June 2020 has been an exciting month for BIOCHEM project. Read our newest experimental results about how to convert proteins into volatile fatty acids, the first step of the carboxylate platform.

Project BIOCHEM is coming to an end soon. It has been a very fruitful project with many results contributing to the development of bioprocesses for converting residues into volatile fatty acids. And many more to come! This week we will be reviewing some of the published results

Proteins are a frequently overlooked substrate in anaerobic fermentation. In this BIOCHEM paper, #RiccardoBevilacqua and coauthors shows how the individual amino acids making up the proteins are converted through acidification into each VFA. sciencedirect.com/science/articl…

Cadastre-se para o seminário "#Economiacircular vs indústria de #conservas de peixe 🐟 e marisco 🦞" 📆 nesta quarta-feira, 18 de novembro ⏲️às 14h00 de #Portugal 👉docs.google.com/forms/d/e/1FAI… Interreg España-Portugal @feup_porto

How to model protein fermentation into VFA? Stoichiometry and kinetics are not easy to predict. @AlberteRegueira et al. provide a comprehensive model reconciling experimental data and metabolic models. Ultimately, a tool to design fermentation processes sciencedirect.com/science/articl…

An-Ping Zeng gave in this review: "New bioproduction systems for chemicals and fuels: Needs and new development" a whole perspective on the requirements of new biorefineries to avoid costly substrates and move to a real circular economy sciencedirect.com/science/articl…

The main design variable to manipulate the selectivity of acidogenic fermentation is pH. In this just accepted paper, Riccardo Bevilaqua et al. show how pH affect protein conversion into VFA, which is itself dependent of the protein amino acids. Not easy! sciencedirect.com/science/articl…

Cells can harbour a limited amount of enzymes. How these enzymes are allocated explains the shift from lactic acid to butyric and acetic acid in glucose fermentation. @AlberteRegueira provided a model in a collaboration with TU Delft researchers onlinelibrary.wiley.com/doi/10.1002/bi…

Ludwig Selder et al. showed how in-situ product removal can be a key for high propionate productivity in a co-culture transformation (glucose + xylose -> lactate -> propionate + acetate) The very promising lactate platform!! rdcu.be/caNid

The thesis of Riccardo Bevilacqua, fully integrated in Project BIOCHEM featured today in the USC journal This thesis shows how experimental work guided by mathematical models can reach further in bioprocess development. #CircularEconomy #WellDoneRiccardo

Just published a great collaboration in the Biochem Project between VTT and Technical University of Hamburg. Producing short and medium chain carboxylates with comprehensive coculture selection and in-situ product removal by electrodialysis sciencedirect.com/science/articl…