Schizophrenia is a disease in need of new treatments with fewer side effects. Cannabidiol is being researched as a new antipsychotic option: profofpot.com/cbd-antipsycho…

People with low activity of the GABA-A receptor are more susceptible to psychotomimetic effects of THC. Here’s how some cannabis terpenes may help: profofpot.com/thc-psychotomi…

Cannabis has been linked to aggression despite having the opposite effect in most people. A polymorphism in the serotonin 5-HT2B receptor may be one explanation: profofpot.com/thc-aggression…

The cannabinoid CB2 receptor is critical for limiting inflammation. Your risk of many immune diseases may be heightened if you have this genetic variant: profofpot.com/inflammation-c…

The cannabinoid CB2 receptor has important regulatory functions in the brain. Your risk of several psychiatric diseases may be heightened if you have certain genetic variants: profofpot.com/psychiatric-di…

The therapeutic potential of minor cannabinoids is often exaggerated. Here are 5 things you need to know to critically evaluate the latest research: profofpot.com/minor-cannabin…

THCV is a minor cannabinoid which can block activation of the CB1 receptor. Although it had potential in type 2 diabetes, it failed a Phase 2 trial: profofpot.com/tetrahydrocann…

CBDV is a minor cannabinoid with activity in animal models of epilepsy, autism spectrum disorders, and neuropathic pain. Several clinical trials have been initiated in these conditions: profofpot.com/cannabidivarin…

THCA is a minor cannabinoid that can potently activate a nuclear receptor called PPARγ. Although it could be neuroprotective, we have no data from clinical trials: profofpot.com/tetrahydrocann…

CBDA is much more potent at the 5-HT1A receptor than CBD. This could mean improved therapy for nausea/vomiting and anxiety, but clinical trials are lacking: profofpot.com/cannabidiolic-…

CBG is a minor cannabinoid that has a variety of pharmacological activities, but the most unique one is not yet proven: profofpot.com/cannabigerol-c…

CBN is claimed to have sedative and sleep-promoting effects. The problem is that very little of the extensive research on CBN actually support this: profofpot.com/cannabinol-cbn…

Here is how your FAAH enzyme genotype affects pain and response to opioids: profofpot.com/pain-faah-endo…

The endocannabinoid system may be involved in the pathophysiology of depression, but it may also offer new opportunities for treatment: profofpot.com/depression-can…

Serotonin is important for regulating pain, mood, cognition, and more. Here is why the serotonergic system is important for certain effects of THC and CBD: profofpot.com/serotonin-cann…

How are endocannabinoids involved in post-traumatic stress disorder (PTSD) and how might cannabinoids be useful for treatment? profofpot.com/ptsd-cannabino…

Your genetics determine part of your risk for developing PTSD. Genetic variants in the cannabinoid CB1 receptor and FAAH enzyme contribute to this: profofpot.com/ptsd-endocanna…

The noradrenergic system is not as famous as the serotonergic or dopaminergic systems, but it is still important for several effects of cannabinoids: profofpot.com/noradrenergic-…

Tetrahydrocannabiphorol (THCP) is the latest cannabinoid. What do we actually know about it and what could happen once it is commercialized? profofpot.com/tetrahydrocann…

You may have heard that CBD is a great way to boost your levels of anandamide. I evaluate the evidence and see that the case for this is weak: profofpot.com/can-cbd-really…