We are excited to share our most recent publication, led by Lucas Miller - wherein we use structural & biochemical techniques to uncover the site of 8-oxo-rG recognition by polynucleotide phosphorylase & its impacts in-vitro & in-vivo! #whatstartshere 🤘🏾pnas.org/doi/10.1073/pn…

🙏Our latest paper on MenT3 in vivo with xibing, Tim Blower, Olivier Neyrolles rdcu.be/dZle4 MenT3 targets serine tRNA in vivo/MenT3 is active under standard growth condition/The CCAse PcnA counteracts MenT3 activity. Fondation pour la Recherche Médicale , ANR - Agence nationale de la recherche, CBI Toulouse

Extracellular Calcineurin-like phosphoesterases foster and signal altruistic behavior in bacteria This new work with Kumaran Ramamurthi Vivek Anantharaman and colleagues uncovers a new role for extracellular calcineurin-like phosphoesterases in bacteria. The calcineurin-like

How to write an excellent Review article Nature Reviews Bioengineering nature #PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #Research #Science

Comparative analysis of 43 distinct RNA modifications by nanopore tRNA sequencing #tRNA2024 biorxiv.org/content/10.110…

Perfect timing! our latest paper on #tRNA engineering is now published, coinciding with the ongoing #tRNA2024 conference. This publication is the result of a phenomenal team effort with Jeffery Tharp academic.oup.com/nar/article/do…

New modulatory N-linked glycosyltransferase complex subunit, signaling and bone-development N-linked glycosylation is one protein modification that can be confidently inferred as being present in the Last Universal Common Ancestor of all life. The inferred ancestral version of

Mycobacterial methionine aminopeptidase type 1c moonlights as an anti-association factor on the 30S ribosomal subunit biorxiv.org/cgi/content/sh… #biorxiv_biochem

How are mRNAs recruited to the ribosome small subunit in bacteria? Super cool story highlighting the role of bS1. Long standing basic questions answered there 🔬 science.org/doi/10.1126/sc…

We are excited to share our latest work on the cooperation between RNA polymerase and the ribosome in bacteria: science.org/doi/10.1126/sc… The work was supported by IGBMC, Inserm, CNRS 🌍, -, @ERC_research, IMCBio Graduate School, and Instruct-ERIC. 1/7

More ribosome structures solved by RAPPL (collaboration with slavica pavlovic djuranovic and Yaser Hashem Labs). This one is novel bacterial ribosome structure from 2ml culture and using method described in our preprint. biorxiv.org/content/10.110…

It's a great pleasure to share our latest collaborative work detailing the composition and structure of the highly rRNA-fragmented mitoribosome from Apicomplexa, such as Plasmodium falciparum and Toxoplasma gondii, now out in Nature Communications rdcu.be/d3R8C

Thank you to Nathan P. Bullen and Aaron Whiteley for the beautiful review of our NARPs paper.

Excited to share our new work on the proline-rich antimicrobial peptide Api137, which disrupts large ribosomal subunit assembly and induces RNA misfolding. Big thanks to the Spahn & Hoffmann groups for this amazing collaboration! rdcu.be/d5RsS

Now published Science Magazine: TIR signaling activates caspase-like immunity in bacteria We report a new immune molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase Congrats @FrancoisRousset & Ilya Osterman! science.org/doi/10.1126/sc…

Another cADPR isomer involved in bacterial immunity has been discovered. For me, N7 was the least expected position; I was sure it would be N3, but no... So, there are two more positions for cyclization that should be discovered: N3 and -NH2. More Thoeris systems are waiting! :)

Novel insights into the tRNA cleavage activity of the PARIS bacterial immunity system and the expansion of viral tRNAs enabling evasion of host defense. Thanks to Christophe. Rouillon and David Bikard for having us in this project! biorxiv.org/content/10.110…

After many years in the making, this story is finally published! In the updated manuscript on BREX DNA recognition, we reveal that modifying the system's specificity can surprisingly enhance anti-phage defense. nature.com/articles/s4146…

You know you have found your science buddy when you are both saying ‘I like the way you think’

In our newly published study we show that the proline-rich antimicrobial peptide (PrAMP) Bac5 has a distinct mode of interaction with the ribosome compared to other PrAMPs…academic.oup.com/nar/article/53…