Now in #EJPC European Society of Cardiology Journals, Christian Faaborg Andersen MD MGH IM Residents 🔎s Lp(a) testing 🧪 across Mass General Brigham 2000-2023

66,937 Lp(a) assays
5.8% w/ coronary 🫀 dz had testing
⬇️ testing in women (OR 0.73), Black pts (0.58)
Testing more common *after* CHD dx
👇
academic.oup.com/eurjpc/advance…

Congratulations to our Broad genomics team on this phenomenal achievement – just in time for #DNADay2024 !

We were honored to host Dr. Monica M. Bertagnolli Monica Bertagnolli and Josh Denny Josh Denny at Broad Institute for a discussion on AllofUsResearch and its progress. Thanks to all the Massachusetts leaders and scientists who made this event a success! allofus.nih.gov/news-events/an…

The comment period for the proposed Board of Cardiovascular Medicine is now open.

The ABMS is interested in hearing from cardiologists as to how a separate, independent CV Board would benefit both clinicians and patients.

Make your voice heard: CVBoard.org/get-involved/

📣 Make your voice heard!

Share your support for an innovative approach to CV medicine certification.

Take advantage of the open comment period to highlight the need for a new, independent Board of Cardiovascular Medicine.

CVBoard.org/get-involved/

Asclepius (Greek god of Medicine) would be impressed by power of genetic Polygenic Risk Score 🔥 High risk population (in red) be considered for aggressive therapy even > 130 of LDL-C. Our presentation #EASPrev2024 Data from 48,881 adults, CARDIO inCode-Score CHD PRS analysis.

A Welcome to the Era of Genome Editing today NEJM
Overview George Q Daley
nejm.org/doi/full/10.10…
Casgevy for Sickle-Cell Disease
nejm.org/doi/full/10.10…
Casgevy for Beta-Thalassemia
nejm.org/doi/full/10.10…

mtDNA heteroplasmy dynamics are so complex, even paradoxical. To understand why, we combined precise mtDNA editing w/a new method SCI-LITE. In dividing cells, selection (not drift) acts on cell (not intracellular) fitness to shape population heteroplasmy. rdcu.be/dFDCY

Congrats to my better half! nejm.org/doi/full/10.10… NEJM Vertex Pharmaceuticals

Out today in JAMA, in this Viewpoint available with free access, Jason H. Wasfy, M.D., James Januzzi Jr MD, and I pose the question:

Is Myocardial Infarction Overdiagnosed?

jamanetwork.com/journals/jama/…

GLP-1Ra Spending would likely have been even higher if not limited by manufacturing limitations statnews.com/2024/04/24/wei… by Elaine Chen STAT

Genetics underlying premature CAD in #SouthAsians remains understudied! Disaggregated studies of genetics and epigenetics crucial for this population ⁦OurHealth⁩ ⁦Romit Bhattacharya⁩ ⁦⁦⁩⁦Sarju Ganatra, MD, FACC⁩ ⁦Pradeep Natarajan⁩ ⁦Broad Institute⁩

Thank you Dr. Monica M. Bertagnolli for your enthusiastic support of the AllofUsResearch Program! It was an honor to be able to share our work with policymakers, innovators, and scientists dedicated to developing our national health research infrastructure.

Thank you for visiting Broad, Dr. Monica M. Bertagnolli! It was an honor hosting the AllofUsResearch team, and we are extraordinarily proud to be partners in the program.

Anyone working with population descriptors in legacy genomic data ✋ - check out this NIH virtual workshop May 28-29, genome.gov/event-calendar…

Thank you Broad Institute for hosting me at your genome center and for partnering with the AllofUsResearch Program! We are so proud of its impact, especially in helping to make sure all Americans are represented in #NIH -supported research.

An incredible honor to present our work on cardiovascular genetics to Dr. Monica M. Bertagnolli, Josh Denny, AllofUsResearch staff, & local officials / colleagues Broad Institute & highlight the transformative impact of AoU!

Definitely lives up to the hype cc José Javier Fuster

The Hindu–Arabic numeral system was invented between the I and IV centuries by Indian mathematicians. The system was adopted in Arabic mathematics by the IX century more widely known through the writings in Arabic of the Persian mathematician Al-Khwārizmī

Polygenic Risk Scores & Coronary Artery Disease:

•Buu Truong et al. explore the impact of CAD polygenic risk scores (PRS) on clinical risk factors
•High CAD PRS linked to 1.35-fold ⬆️ risk (per SD) of incident CAD
•Findings suggest personalized prevention strategies are crucial