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Why are statins administered at night?

In this tweetorial I'll discuss the mechanistic and historical reasons for the frequently used QHS dosing schedule. And why it's often unnecessary.

But before we get there, I'm curious: when do you prescribe/order/take statins?

Consider:

GLP1s can be made for <$5/month

But they’re not. Why? Is it to provide the best possible support of pts? If not, we should be talking more about this JAMA study

cnbc.com/amp/2024/03/27…

New work led by Mohammad Saadatagah Mohammadreza Naderian in JAMA Cardiology underscores that not all CHIP 🩸🧬 is the same. TET2 CHIP assoc'd w/ ⬆️ IL-6 and AF risk, esp when clones are large.

jamanetwork.com/journals/jamac…

Art Schuermans Alex Bick Pradeep Natarajan Iftikhar J. Kullo Christie Ballantyne

For over 4 million insurees, 'free' polygenic risk scores for 8 conditions (including heart disease, multiple cancers, type 2 diabetes, atrial fibrillation) that were deemed to be actionable by 71% people in a pilot study
statnews.com/2024/04/09/mas…

Whirlwind conference
🌀

Great to meet friends old and new! With a side of eclipse 🚀🔥🌅

#ACC24

Twin epidemic of Premature Heart Disease and Type 2 DM in #SouthAsians ⁦Dinesh Kalra, MD⁩ eloquently outlining the role of #LpA #Things we know, Things we don’t know and Unknown of Unknowns! ⁦Anandita Agarwala Kulkarni, MD FACC⁩ ⁦Sam Tsimikas, MD⁩ Highest burden of elevated LpA in the world!

Many thanks Saurabh S Dani, MD, MSc !
Looking forward to collaborating with you at Lahey Hospital !

Here we go!
#SouthAsianCVD 🌶️🫀💪🏽

Many thanks Snehal Bhatt for your support of OurHealth

Such an exciting session!

Looking forward to pushing forward on #SouthAsianCVD
🌶️🫀💪🏽

“One of the most important takeaways of the MASALA study is the power of ownership.” - Jaideep

What a fantastic crew and great session to end #ACC2024 !

Anandita Agarwala Kulkarni, MD FACC Romit Bhattacharya Aarti M Thakkar Salim Virani Dinesh Kalra, MD Johns Hopkins Cardiology MASALA Study

prevalence and pathophysio of CVD in south Asians. Salim Virani

‼️ South Asia = epicenter of premature heart disease.
‼️ Even amongst South Asians the risk is NOT the same
‼️there IS hope to mitigate risk (work on modifiable risk factors i.e diet, etc) #ACC2024

😂 Alright! I won an award at #ACC24 !

Thank you so much for sharing our work!

OurHealth
Pradeep Natarajan
Anandita Agarwala Kulkarni, MD FACC
Jaideep
Dinesh Kalra, MD