this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to

There’s a fundamental difference between taking an existing process and applying AI agents to it vs. taking a process from scratch and designing it from the ground up for AI agents. The gap we’re going to see will widen between the teams and companies that are able to do the

June 1983. A 28-year-old Steve Jobs walks into a design conference in Aspen, Colorado. He asks the room who owns a personal computer. Nobody raises their hand. He says “Uh-oh.” Then he spends the next 55 minutes describing the next four decades of technology. Jobs told the

“AI exposed jobs may increase hiring and attract higher wages. It all depends on a) elasticity of consumer demand and b) number of AI exposed tasks in a job.” This is a key point. We’re going to see lots of AI automation emerge that has the opposite effect that we expect,

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Anthropic is building OpenClaw faster than OpenAI is. OpenClaw proved a concept the entire industry had been theorizing about: your AI agent should live on your computer, not in someone else’s cloud, and you should be able to talk to it from anywhere. 318,000 GitHub stars. Then

"The industry has to reconfigure in so many ways because the customer is not the human anymore. It's like agents who are acting on behalf of humans.” Andrej Karpathy in conversation with sarah guo on No Priors.

Anthropic has been shipping computer use for 17 months. This is the fourth version and the first one that actually changes how developers work. October 2024: computer use launched as an API beta. You spun up a Docker container, Claude took screenshots, counted pixels to find

One of the biggest lessons thus far in building AI agents is you have to be brutally unsentimental in your architecture. The models get better and better at handling things you previously built scaffolding for, you need to ruthlessly jettison your prior tech to get those new

Carl Vellotti has a folder in his Claude Code workspace called "people." Each file is a dossier on someone he works with. What they care about, what they've said in meetings, what their priorities are. He connected it to Granola, the meeting transcriber. After every meeting,

some more ramblings from working at Anthropic. I've been asked a few times what the single most important thing a growth marketer should be doing with AI that most aren't. surprise, it's not just a single specific task. after running dozens of growth workflows through

Mythos from Anthropic is another clear reminder that there’s absolutely no wall in model capability progress right now. Meaningful double digit gains on critical benchmarks, and it appears we’re going to keep up getting insane gains from the other labs. And as coding and tool

Zuckerberg paid $14.3 billion for a 28-year-old who had never trained a frontier model. Nine months later, that bet just shipped. The benchmark table tells you exactly what kind of lab Wang built. Muse Spark leads or ties Opus 4.6 and GPT 5.4 on multimodal perception, health

The companies spending $200K/year on AI seats and seeing zero productivity gains are all making the same mistake. They're giving every employee access to the same foundation model with zero shared context. Each person starts from scratch every conversation. The PM asks Claude to

Text with a founder/ceo this morning:

I think everyone is substantially underestimating the total demand for software and automation in areas that don’t feel like “software”. Not talking about software that’s another app on your phone. Software that just automates things for companies all day long. Most companies

Cancer is cured by AI. GitLab founder Sid Sijbrandij was diagnosed with stage 4 spinal cancer. Every trial rejected him. His doctors had nothing left to offer. So he stopped being a patient. He built an AI research team. Fed them 25TB of his own medical data genomics, scans,

Another week on the road meeting with a couple dozen IT and AI leaders from large enterprises across banking, media, retail, healthcare, consulting, tech, and sports, to discuss agents in the enterprise. Some quick takeaways: * Clear that we’re moving from chat era of AI to

This is really accurate. As much as we all want to drink the vibe coding kool-aid, the reality is that 90%+ of all code in a company is maintaining and migrating existing stuff that is complicated and messy. You can definitely vibe code the remaining 10% but unless there is a

Today we're releasing Personal Computer. Personal Computer integrates with the Perplexity Mac App for secure orchestration across your local files, native apps, and browser. We’re rolling this out to all Perplexity Max subscribers and everyone on the waitlist starting today.