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A versatile and inexpensive method to generate oligonucleotide probes for fluorescent in situ hybridization experiments bit.ly/3LXrvZi

Now out in eLife – our epic journey into the heart of polyQ to deduce the structure of an amyloid nucleus. Spoiler: it’s not #LLPS. Even more surprising, oligomerization blocks nucleation!

A molecular optomechanics approach reveals functional relevance of force transduction across talin and desmoplakin | Science Advances science.org/doi/10.1126/sc…

cells are resilient

Why is there so much disorder in eukaryotic proteins? What is its relationship with condensates? Why can some proteins be saved but others get degraded? After years in the making, we think we have answers and they're all connected. Excited to share a 🧵: biorxiv.org/content/10.110…

#Worm23 massive speed distribution

Great example of how IDPs help organism survive in extreme conditions.

A beautiful tool for tracking protein spatial information!

Day 26 of great biology papers. "Reconstitution of ribosome self-replication outside a living cell," by Kosaka et al. (2022). This paper marks the first time that scientists coaxed ribosomes to make other ribosomes entirely in a test tube. A step toward synthetic life. *******

I am like “OMG”! Whenever I watch this. Killer T cell release toxins to kill cancer cells. Would the accumulation of toxins in the nucleolus be a defense mechanism for cancer cells? Are toxins positively charged so they can enter into the nucleolus?

OoLEN just published their next paper. Have a look at which methods it takes to solve the #OriginOfLife Thanks to all the amazing authors for their hard work 💪🥳 arxiv.org/abs/2308.11665

#FactFriday Did you know that Canada has the lowest spending on research and development among the #G7, with no increase in the last 20 years? #Canada is falling behind in research and development and it's time we catch up 🕐

🎉It's finally out!! We show that intramolecular interactions in IDPs are strong enough to hold in the cell, but flexible enough to respond to cellular volume changes. A labor of love of many people, mainly recent graduate David Moses and Karina Guadalupe. shorturl.at/cdyR2

Now online! Direct observation of a condensate effect on super-enhancer controlled gene bursting dlvr.it/T177rp

Don’t miss the next What can #RNA do? Online Seminar series this January 29th 16h-18h EDT. This month’s topic: RNA in #condensates. See details below and register! rnacanada.ca/seminar-what-c…

This is the end of the world as we know it, if this is reproducible! The new era of functional modeling has begun. I took a transcription factor with an unknown structure and folded it with its recognition sequence embedded in longer DNA. AlphaFold3 accurately positioned the

First paper of our lab today nature by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! EMBL doi.org/10.1038/s41586…

Discover how unique ribosome fingerprints could revolutionize early cancer detection with non-invasive, portable scanners able to detect cancer with near-perfect accuracy. #RNA #CancerResearch #EarlyDetection #Ribosome #Genomics #NanoporeSequencing science-tldr.com/news/ribosome-…

Excited to share our recent work on the power of RNA to encode physical information and how this can be embedded in the genetic code biorxiv.org/content/10.110…

Congratulations to PhD student @LucasPhilipp1 on his first preprint! 🎉 He used Hi-C data to reconstruct the 3D conformations of dinoflagellate chromosomes 🦠🧬 And contrary to the prevailing model, they aren't liquid crystalline! 😯 biorxiv.org/content/10.110…