Mass General and Harvard Medical School Investigator Gary Ruvkun, PhD, has won the 2024 The Nobel Prize in Physiology or Medicine. He is honored for his discovery of small regulatory RNAs. Congratulations! Learn more: spklr.io/6019vzIW

Geoffrey Hinton wins Nobel Prize in Physics | University of Toronto utoronto.ca/news/geoffrey-…

Read the latest #research on #Nucleolar RNA Polymerase II, #ribosome biogenesis, and #protein synthesis (in final form). Congrats to first-author Negin Khosraviani and our amazing coauthors and collaborators. doi.org/10.1038/s41467…

We are recruiting! Princess Margaret Cancer Centre in Toronto is recruiting an early career cancer research scientist at Assistant Professor level. Apply! Spread the word! nature.com/naturecareers/…

Check out our latest pre-print: we show that the LINE-1 retrotransposon is a potent source of chromosomal rearrangements and instability in addition to insertional mutagenesis using shotgun and long-read WGS. Kathleen Helen Burns Jennifer Ann Karlow biorxiv.org/content/10.110…

Living the targeting #RAS era 🤯🤯🤯 KRASKickers #G12C #G12D cell.com/trends/cancer/…

nature.com/articles/s4146…

Our study on T-ALL heterogeneity is out! We show ~1/3 of T-ALLs express inflammatory/stem signatures and are sensitive to venetoclax. Huge congrats to @gowerfulScience for leading the way, Soheil Jahangiri, and the entire team! science.org/doi/10.1126/sc…

🎉 CRI is proud to announce our Fall 2024 class of CRI Irvington Postdoctoral Fellows and Immuno-Informatics Fellows! Meet the exceptional researchers who are investigating novel therapeutic strategies to harness the immune system against cancer: bit.ly/4hSZlvB

Thrilled to share our latest work in nature! We show how cancer cells navigate DNA replication despite DNA damage, revealing new insights into genome stability. Huge thanks to my incredible collaborators! Check it out here: nature.com/articles/s4158…

If you want to know what have we learned in the field of R-loop homeostasis in 2023-24 and the questions coming ahead Paula Universidad de Sevilla Cabimer R-loop homeostasis in genome dynamics, gene expression and development sciencedirect.com/science/articl…

Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment academic.oup.com/narcancer/arti… IDIBELL IDIBGI Institut d'Investigació Biomèdica de Girona Institut Català d'Oncologia By fantastic Roderic Espin! And thanks to many - Aytes & Vinyals teams! IDIBELL IDIBGI Institut d'Investigació Biomèdica de Girona Institut Català d'Oncologia Centres CERCA

Review: Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers brnw.ch/21wRhmB By Sarah C. Moser and Jos Jonkers from The Netherlands Cancer Institute Oncode Institute

New Links: Cancer and Immune Evasion🧬 Recent study found that cancer cells without the tumour suppressor protein p53 become more resistant to the body's immune response. A study led by Daniel De Carvalho at University Health Network’s Princess Margaret Cancer Centre. uhnresearch.ca/news/new-links…; doi.org/10.1158/2159-8…

🚀Our new review Nature Reviews Molecular Cell Biology explores how nuclear and genome organization drive DNA double-strand break repair! 🧬 This collaboration spans 🇺🇸(Irene Chiolo), 🇨🇭(altmeyerlab), 🇫🇷(Gaëlle Legube lab Chromatin Repair), &🇨🇦(@karimmekhail); science knows no borders! 🌍 📖 rdcu.be/edViW Please 🔄❤️

⁦#InterferonPower! Hongbo Chi⁩ &co show ⁦nature⁩ that VDAC2 deficiency facilitates tumor destruction by T cell-driven IFNgamma by causing mitochondrial (mt) damage & mtDNA sensing by cGAS–STING, which drives type I IFNs & tumor death! nature.com/articles/s4158…

Outstanding preclinical work being done by Parasvi Patel⚡ and the team at Mass General Cancer Center and Harvard Medical School in support of the Stand Up To Cancer Catalyst®️ Bristol Myers Squibb Team! #KRAS #Mirati #colorectalcancer #aacr25

RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science science.org/doi/10.1126/sc…

From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science go.nature.com/44hKo29

Food can also be "anti-medicine" Very nice mechanistic work from Overacre Lab in Cancer Discovery Sucralose consumption ablates cancer immunotherapy response through microbiome disruption. aacrjournals.org/cancerdiscover…