🔬 New grant featured by Pitt Health Sciences: "Senthil Sadhasivam, professor of anesthesiology and perioperative medicine, School of Medicine, has been awarded a $16.8 million U01 grant from the National Institutes of Health (NIH) and the National Center for Advancing Translational

Kappa agonists from Iboga: nature.com/articles/s4146…

🥳New pub! Kappa opioid receptor agonists are clinically effective in treating chronic itch, but how do they work? We've found which neurons carry itch from the spinal cord to the brain and show kappa agonists inhibit these cells to suppress scratching 🦟 science.org/doi/10.1126/sc…

🎉A New Special Issue "Precision Medicine in Anesthesia and Pain" is open for submission! 👨‍⚕️Guest Editor: Dr. Paramita Basu Paramita Basu 📅Deadline: 30 May 2025 🔗mdpi.com/si/215784 🔔 We welcome your submissions! #MedTwitter #mdpijpm #Anesthesia #Pain MDPI Medicine & Pharmacology

Distinct circuits and molecular targets of the paraventricular hypothalamus decode visceral and somatic pain: Neuron cell.com/neuron/fulltex…

Cryo-EM structure of small-molecule agonist bound delta opioid receptor-Gi complex enables discovery of biased compound | Nat Commun doi.org/10.1038/s41467…

🔬 Research Rounds on October 22 at 3:00pm: Dr. Paramita Basu Paramita Basu will present “Deciphering the Mechanism of Sex Differences in Protein Kinase A Signaling of Chronic Postsurgical Pain." 📅 Event details: buff.ly/3MeICoN

It's Spooky Brain season! 🧠👻🧟‍♂️ Staining in the prefrontal cortex with 🟣SMI-32 for neurons (one of the best markers for pyramidal cells I've seen), 🟢Iba1 for microglia, and 🔵Dapi for nuclei! Happy #FluorescenceFriday!🔬

Happy to share our latest review on Y2 receptors in pain and itch, extending insights from the NPY Y2 paper. Pitt Anesthesiology and Perioperative Medicine sciencedirect.com/science/articl…

This is honestly an AMAZING resource! 😍

Our new peripheral DREADD is now available via Addgene Please RT addgene.org/228902/ Paper Cell here: cell.com/cell/abstract/…

My colleagues Pranav Prasoon, Kei Suzuki, and I are happy to share this research topic and our editorial article, "Understanding and Managing Diabetic Neuropathy: Current Perspectives and Future Directions." Pitt Anesthesiology and Perioperative Medicine Frontiers - Neuroscience nam12.safelinks.protection.outlook.com/?url=https%3A%…

Thanks to Ream Al-Hasani, Charles Chavkin, and committee members for organizing a great Kappa Therapeutics conference!! I enjoyed presenting my work on kappa opioid receptors and chronic postsurgical pain. #KappaCon2025

Enhancing the Cre-loxP system: Two new genetic tools – roxCre and loxCre – can improve the performance of the Cre-loxP system for making genetic modifications in vivo. elifesciences.org/reviewed-prepr…

Wow! Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord nature.com/articles/s4159…

USASP Acute to Chronic SIG had a great session with seven outstanding speakers at #usasp2025. We congratulate all of them for sharing their fantastic work! Aubin Moutal Clémence 🧠 Navia Lab Marco Loggia MGH Martinos Center mollie meffert Paramita Basu US Association for the Study of Pain

New paper out from my lab and Dr. Akopian's lab. First of its kind to characterize mechanically-gated trigeminal neurons in non-rodent higher order species. #painresearch #nonrodentmodels eneuro.org/content/early/…

Surgeries are a common source of #pain in the clinic. Check out our new paper published today in PNAS exploring how stress can lead to enhanced pain after surgery. We found that targeting prolactin can improve outcomes in females. PNASNews. pnas.org/doi/10.1073/pn…

Online now: Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal dlvr.it/TKnZ4c