Structure prediction of alternative protein conformations 構造変化の予測に新しい手法を、と言うお話 nature.com/articles/s4146…

Structural shifts in TolC facilitate Efflux-Mediated β-lactam resistance nature.com/articles/s4200…

Congratulations to our new Dr Löbel! Department of Biochemistry at Oxford University Kavli Institute for Nanoscience Discovery, Oxford thanks to Paul Elliott Lab and David Drew

Potassium dependent structural changes in the selectivity filter of HERG potassium channels カリウム依存的なhERGの構造変化に関して nature.com/articles/s4146…

SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis nature.com/articles/s4146…

Interdomain-linkers control conformational transitions in the SLC23 elevator transporter UraA nature.com/articles/s4146…

De novo design of Ras isoform selective binders de novoデザインでお馴染みのグループから新作。今回は様々なガンで暴れ回るRasアイソフォーム達特異的なbinderを作り機能を阻害する話 biorxiv.org/content/10.110…

Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation nature.com/articles/s4146…

Mechanistic insights of substrate transport and inhibitor binding revealed by high-resolution structures of human norepinephrine transporter nature.com/articles/s4142…

Small LEA proteins mitigate air-water interface damage to fragile cryo-EM samples during plunge freezing クライオ電顕で度々問題になる気液界面問題をクマムシなどが持つタンパク質で克服できるかも という、お話 nature.com/articles/s4146…

Structures of the Mycobacterium tuberculosis efflux pump EfpA reveal the mechanisms of transport and inhibition nature.com/articles/s4146…

Single-molecule digital sizing of proteins in solution nature.com/articles/s4146…

Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates ヒト以外の霊長類に対してだけど、早速こーゆー仕事が出てきた cell.com/cell/fulltext/…

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site nature.com/articles/s4146…

Cell swelling enhances ligand-driven β-adrenergic signaling 浸透圧により膨張した細胞において、アルGPCRが『好む構造』を取るかもと言うお話。膜の厚みの微妙な変化が機械刺激応答でないと考えられる膜タンパク質に影響与えててもおかしくは無さそうだな nature.com/articles/s4146…

Divergent mechanisms of steroid inhibition in the human ρ1 GABAA receptor nature.com/articles/s4146…

Divergent sensory pathways of sneezing and coughing アレルギーだとくしゃみ、風邪だと咳、２つの違いは感覚神経の経路の違い と言うお話 cell.com/cell/fulltext/…