New preprint! In chronic stress, cells must balance their own survival with tissue-level roles. Prior work has emphasized stress-induced drivers of cell death, but what happens to surviving cells? How do they adapt, and how do their changes connect to long-term dysfunction? (1/n)

Excited to share our preprint on metabolic differences in the vaginal #microbiome. We find key differences in fatty acid metabolism among #Lactobacillus species & leverage those findings to identify a potential new therapy for bacterial vaginosis (BV) & #WomensHealth 🧵 (1/n)

ICYMI over the holidays, amazing new PerturbView tech from Takamasa Kudo, Eric Lubeck, and others at Genentech. Enables OPS in diverse cell types and tissue, combined with iterative and multimodal phenotyping. Check out our preprint for more! biorxiv.org/content/10.110…

Excited to share my postdoctoral work is now online Cell thanks to all the coauthors that contributed to this work!

Our new preprint describes “CROPseq-multi”: a versatile solution for multiplexed perturbation and decoding in pooled CRISPR screens doi.org/10.1101/2024.0… Reagents on Addgene: addgene.org/browse/article…

Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens biorxiv.org/cgi/content/sh… #biorxiv_micrbio

30-COLOR DNA-PAINT at 3D sub-15 nm RESOLUTION. We are overly excited to announce the publication of our latest work “Spatial proteomics in neurons at single-protein resolution” in Cell. Huge collaborative effort led by Eduard Unterauer. 1/9 cell.com/cell/fulltext/…

Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans | eLife elifesciences.org/articles/93629

I’m excited to share a new manuscript from my PhD! doi.org/10.1101/2024.0… We performed a genome-wide optical pooled screen (OPS) and identified hundreds of novel Ebola virus regulators.

We're hiring! We are seeking an exceptional postdoc associate to help us work on solving the antibiotic resistance crisis, details and apply here: broadinstitute.avature.net/en_US/careers/…

New preprint up, showing how snowflake yeast overcome one of the greatest limitations on the evolution of multicellularity: diffusion. They do so by leveraging emergent biophysics to rapidly flow media through their bodies, like a sea sponge. 1/28

What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

Our paper! 🪩 "Spatial mapping of mobile genetic elements and their bacterial hosts in complex microbiomes" Full text link: doi.org/10.1038/s41564…

We're hiring for a postdoc to work with us on the technical development and deployment of optical pooled screening (OPS) technology! Details and apply here: broadinstitute.avature.net/en_US/careers/…

An MIT team continuously imaged individual scales as they grew out from the butterfly wing’s membrane, revealing for the first time how a scale’s initially smooth surface begins to wrinkle to form microscopic, parallel undulations news.mit.edu/2024/new-findi…

Out now in @cellcellpress - our story about metabolic differences in the vaginal microbiome led by Meilin Zhu Broad Institute in collaboration with the Doug Kwon at Ragon Institute and others: cell.com/cell/fulltext/…

Available now via bioRxiv is our preprint on live-cell transcriptomics with engineered virus-like particles Broad Institute biorxiv.org/content/10.110…

Excited to share how Jacob Borrajo Anna Le and I are enabling the future of profiling dynamic cellular processes! We built a synthetic RNA export pathway for cells to "self-report" their transcriptional states in real-time. Big thanks to the entire team! biorxiv.org/content/10.110…

Can Dense Associative Memory (DenseAM) generate novelty while trying to perfectly memorize? Yes! Our poster (spotlight🏆NeurIPS Conference) explores unique connections between DenseAM and kernel density estimation (KDE) to unlock novel generation in DenseAMs.