Bye bye Owain James Bryant, our adorable and v. supportive neighbor. All the best to your new journey in the 🇺🇸.

Lifelong dream - seeing a Spider Orchid ✅ …. WOWWWWWW!!!

Textbooks say multipass membrane proteins get into the ER via the same channel used for secretion, but it turns out that they actually recruit their own dedicated translocon that latches the secretion channel shut. Exciting collab with Luka, Min &co www2.mrc-lmb.cam.ac.uk/pathway-for-ma…

Massive news: eLife to abolish accept/reject decisions: papers will just be “peer reviewed”. Others can argue about this, but lots of interesting consequences. 1/9 elifesciences.org/articles/83889

With lots of new data from the pre-print! I think we finally have a (partial) answer to how alpha-helical proteins get inserted into the mitochondrial outer membrane in human cells. science.org/doi/10.1126/sc…

Picking up ~ANOTHER PRIZE~ for this very good boy! He came second place in a scurry competition at a gundog fair…and not just the novice round, but the advanced round! Well done, Talisker! 👏👏👏 😊

Visualizing translation dynamics at atomic detail inside a bacterial cell nature.com/articles/s4158…

I am ecstatic to finally share our work in nature where we investigated BlaR1, a signalling protein that controls resistance to β-lactam antibiotics in the major human pathogen, Methicillin Resistant Staphylococcus aureus. #MRSA #AMR #cryoEM nature.com/articles/s4158… (1/n) 🧵

💥We're hiring! Two fully-funded postdoc positions at my lab at the NIH intramural program in Frederick, MD. We are mapping the structure of whole proteomes using crosslinking MS and structure modeling. At one of the most dynamic scientific institutes! Links are below.

2X BBSRC PDRA opportunities, Chung lab, Department of Pathology, University of Cambridge. Please see below for graphical abstract. dropbox.com/s/jetbpci9dxa9… jobs.cam.ac.uk/job/39648/ jobs.cam.ac.uk/job/39649/

Finally!!! It’s out! Congrats KK!!! Yippeee!!! Membrane-localized expression, production and assembly of Vibrio parahaemolyticus T3SS2 provides evidence for transertion | Nature Communications rdcu.be/c6GyM nature.com/articles/s4146…

You're not seeing double! Many ABC proteins are proposed to dimerize. Here Sarah C. Bickers showed that Ycf1p forms a dimer upon proteolytic cleavage and determined a 1st ABC transporter dimer structure. Collaboration w/ @RubinsteinJohn and Samir Benlekbir biorxiv.org/content/10.110…

What is OUP-mediated translation initiation? Find out @ nature.com/articles/s4146…. Fantastic work driven by our dynamic PDRA:PhD duo. Owain James Bryant and Filip Lastovka, ChungLab @CamPathology

As it turns out, the secretion channel Sec61αβγ has a fourth subunit, RAMP4—long overlooked because it falls off in detergent. It holds the pore open and completes the lumenal funnel. This plus exciting structures of TRAP, uL22, & more are now online: biorxiv.org/content/10.110…

Check out our latest paper where we identify a new C-terminal export signal in flagellar Type III secretion substrates which provides further evidence against a subunit capture/chain mechanism for flagellar assembly. doi.org/10.1128/mbio.0…

Published today Steve Johnson and Justin Deme story finally revealing the molecular basis for transmission of uni-directional ion flow into bi-directional rotation of the bacterial flagellum doi.org/10.1038/s41564…

Reducing the complexity of a fascinating molecular motor. Read our Behind the Paper blog, where we detail our journey to deciphering the structural basis for how bacterial flagella shift into reverse gear: communities.springernature.com/posts/let-slip…