Our research on using AlphaFold2 to predict how peptides from disordered regions bind proteins has now been published with Springer Nature in Nature Communications I am very happy to share the updated paper with you 😀 rdcu.be/dwlLa

Regulation of replicative histone RNA metabolism by the histone chaperone ASF1 sciencedirect.com/science/articl…

Now online! SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion dlvr.it/T27Krw

#jobalert Le CEAJoliot recrute ! Un poste de technicien est à pourvoir pour la plateforme #RMN de I2BC Paris-Saclay / CEAJoliot ➡️emploi.cea.fr/offre-de-emplo…

Jessica Andreani, Diego Javier Zea and colleagues at CEAJoliot and I2BC Paris-Saclay show that AlphaFold2 accurately predicts protein interfaces involving disordered regions by combining different delimitations and sequence alignments. nature.com/articles/s4146…

In eLife - the journal: Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe doi.org/10.7554/eLife.…

Deadline approaching for the EMBO workshop "Chromatin dynamics and nuclear organisation in genome maintenance", June 17-20, 2024, Leiden, the Netherlands. Speaker slots available! Register before April 1, 2024! meetings.embo.org/event/24-chrom…….

Using reconstitued complexes, we found that the long KER helix mediates DNA binding and stimulates pombe CAF-1 association with PCNA. Also, the WHD domain behaves differently from other species. Great collaboration with Ochsenbein Francoiz and Geneviève Almouzni. doi.org/10.7554/eLife.… eLife - the journal

Here we are! Looking forward to open it to community in tandem with Krios at Soleil synchrotron arriving soon. Congrats at Stephane Bresssanelli and the I2bc cryoEM platform

New preprint 🚨 We investigated how protein-RNA interface structure evolves by thoroughly analyzing the conservation of contacts among 2022 pairs of homologous interfaces. Work with Ikram Mahmoudi, Chloé Quignot, Carla Martins I2BC Paris-Saclay CEAJoliot

French 3R meeting 2024. Congratulations to Victoria Rojat from IBENS, Amelie Besombes from Institut Jacques Monod Institut Jacques Monod, and Jerome Savocco from @ENSdeLyon for winning the poster price from la Société Francaise de Génétique. SFGénétique SFGénétique.

Applications for AlgoSB 2024 "Structural bioinformatics in the AlphaFold / Deep Learning era" are open until July 14! More details on the website: algosb2024.sciencesconf.org

The team has a postdoctoral position open in Molecular & Cellular Genetics, to study replication fork repair pathways in the nuclear space (M/F) | EURAXESS euraxess.ec.europa.eu/jobs/243923 . application to be sent at [email protected]. Please RT;

Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP: cell.com/molecular-cell… Check this new paper by our lab, Raphaël Guérois' and Cejka Lab where Alphafold, biochemistry and yeast genetics uncover how pSae2/pCtIP activates Mre11 nuclease!

Great news to celebrate today! VU Duc Duy’s masterpiece is out in NatureStructMolBiol! nature.com/articles/s4159…

Team publication Institut Curie CNRS Biologie, Université Paris-Saclay, showing how the nuclear pore environment ensures optimal replication fork restart. Thanks to Tony Carr @GDSC_Sussex , Karol Kramarz @Karel_Naiman. Congratulations to Kamila Kamila Schirmeisen. doi.org/10.1093/nar/gk…

cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers nature.com/articles/s4159…

cBAF makes hemisome-like subnucleosomes that Oct4 binds to! nature.com/articles/s4159…

A reminder that AlgoSB applications are open until next week (deadline 14th July). More information on website linked below 🙂

Excited to share the first part of my PhD work, revealing a major role for HIRA-mediated histone H3.3 deposition in maintaining 3D organization of active chromatin across scales, supervised by Geneviève Almouzni in collaboration with Marc A. Marti-Renom Leonid Mirny biorxiv.org/content/10.110…