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cell.com/immunity/fullt…

biorxiv.org/content/10.110…

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biorxiv.org/content/10.110…

I'm happy to share a highlight from our recent work!

Congratulations to Honggui, Jiankun, and Tan for improving the single-cell 3D genome resolution by a factor of 4 (to 5 Kb). This allowed direct visualization that multiple enhancers cluster to a particular gene promoter at the same time in a single cell. nature.com/articles/s4158…

Sequential activation of transcription factors promotes liver regeneration through specific and developmental enhancers dlvr.it/TLqkhW

We’re Blainey Lab sharing a major update to CROPseq-multi, our versatile system for CRISPR screens that is compatible with individual and combinatorial perturbations, diverse SpCas9-based technologies, and multiple high-content, single-cell readouts. biorxiv.org/content/10.110…

nature.com/articles/s4146…

biorxiv.org/content/10.110…

DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution | Nature Communications share.google/CMnYfQE3s3oiMl…

Spatial-DMT is now published in nature ! For the first time, we can simultaneously map DNA methylation and RNA transcription in tissue context. Great collab with Wanding Zhou lab. Big congrats to Chin Chin , Hongxiang Hongxiang Fu and team! nature.com/articles/s4158…

Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7, link below)

TDAC-seq: Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminase nature.com/articles/s4159…

New online! Regulatory genome annotation bit.ly/4mZGlhW

EpiAgent: foundation model for single-cell epigenomics nature.com/articles/s4159… EpiAgent encodes chromatin accessibility patterns of cells as concise ‘cell sentences’ and captures cellular heterogeneity behind regulatory networks via bidirectional attention.