Proteins, proteins, proteins. How 3,000 blood proteins can help predict 10-year risk of >200 common and rare diseases, beyond genomic markers nature.com/articles/s4159… UK Biobank Nature Medicine

With immense pride and limitless optimism for our country’s future, I endorse Vice President Kamala Harris for President of the United States. I have full confidence that she will lead us to victory in November. -NP

Very pleased to have this grant funded via The Chan Zuckerberg Initiative! CZI Science

Fantastic to have received our first CZI Science grant at Human Technopole to develop machine learning methods for population scale single-cell data - congrats Craig Glastonbury 💪🙌🎉🎉🎉

🚨 Online now! 📰Misexpression of inactive genes in whole blood is associated with nearby rare structural variants 🧑‍🤝‍🧑Thomas Vanderstichele Emma Davenport & colleagues cell.com/ajhg/fulltext/…

🔬Our Gaia Pigino Group unveils mechanisms behind ciliary transport, discovering how anterograde trains switch to retrograde and revealing secrets of cargo binding and potential treatments for ciliopathies. On Cell humantechnopole.it/en/news/mechan…

Gaia is a superstar 😍

It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇 nature.com/articles/s4156…

We’re delighted to have Nicole Soranzo Nicole Soranzo & Yasmine Belkaid Belkaid Lab as our keynote speakers for the HCA General Meeting. You can see the full agenda at events.humancellatlas.org/2024GM/agenda #HCA2024GM

Can we recreate the transcriptional states seen in single-cell atlas projects? In our new preprint we try to do this using large-scale Perturb-seq experiments. Along the way we discuss off-target effects of CRISPR epigenetic editors and identify drivers of key fibroblast states.

📣📣 Variant-to-function dissection of rare non-coding GWAS loci with high impact on blood traits biorxiv.org/content/10.110… 👏 Manuel Tardáguila (con el pueblo 🇵🇸) Nicole Soranzo and co

🌟Excited to be at #ECI2024 with my team & Blagoje Soskic's lab! Do not miss tmr posters from my lab on neonatal immunity by Altea Gjurgjaj and on long-read transcriptomics by Azahara Fuentes as well as talks from Soskic team on B cell genomics by Pietro Demela & PMarchesan!

Have fun everyone😍!

If you are at #ECI2024 and interested in B cell biology, don’t miss today talks from two fantastic phd students in my lab Pietro Demela and PietroMarchesan Human Technopole . #proudPI

Also don’t miss a talk on neonatal immunity from our institute from Cecilia Domínguez Conde and two posters from Cecilia’s lab Altea Gjurgjaj and Azahara Fuentes

Check our paper in nature nature.com/articles/s4158… This is a huge collaborative work combining great basic and clinical science, with important implications for the prevention of atherosclerotic cardiovascular disease. Thanks to all our collaborators and funders!

🧬 A new study co-authored by our Davide Bolognini Alessandro Raveane & Nicole Soranzo reveals that human amylase genes, crucial for starch digestion, underwent multiple duplication and deletion events throughout evolution. 📰 Published in @nature humantechnopole.it/en/news/the-ev…

fun collaboration with the whole team (led by Peter Sudmant & Erik Garrison) nature.com/articles/s4158…

Amazing summary of our amylase paper from folks in Berkeley news.berkeley.edu/2024/09/04/agr…! Cool application for the new pangenome-based genotyping method 🔥 Peter Sudmant Erik Garrison Jason Chin Nicolas Lou Joana L. Rocha Andrea Guarracino Nicole Soranzo Alessandro Raveane

🇪🇺 I have been awarded a European Research Council (ERC) Starting Grant #ERCStG to study how endogenous amidated hormones contribute to the effectiveness of the anti-diabetic drugs GLP-1RA (acronym GLP1RES). 🙏Very grateful to my colleagues and collaborators for their support.