Announcing the 2ND INTERNATIONAL TOP-DOWN PROTEOMICS SYMPOSIUM Oct 3-5, 2023 in Chicago. Join us for this exciting event. Details here>>tdp2023.topdownproteomics.org #proteomics #massspec

Congratulations to Bing Zhang, winner of the 2023 Gilbert S. Omenn Computational Proteomics Award! Your groundbreaking work in proteomics is truly inspiring and sets an example for aspiring scientists everywhere. Thank you for your contributions to the field! #USHUPO2023

#USHUPO23 is a huge success! Many thanks to the organizers Lingjun Li Peter Nemes @HaoLab_GWU, Jeff Savas, Brianna&team for their hard work! US HUPO Congrats! 🎉 Fantastic scientific program! So much fun get together with friends 😀❤️

Histone H4 #proteoforms and post-translational modifications in the Mus musculus #brain with quantitative comparison of ages and brain regions by Nicolas L. Young et al BCMHouston Dr. Nicolas L. Young #histone #PTMs #chromatin #epigenetics #proteomics link.springer.com/article/10.100…

Behold: Heterotypic nucleosomes show that H3 tail acetylation in cis precedes H3K4me3 !!! Mobilization of the substrate histone tail (most likely by charge neutralization) is key ... Dr. Brian D. Strahl EpiCypher, Inc. Kanishk Jain [biorxiv.org/content/10.110…]

We are proud to announce the publication of the cis-acting proteoform-based mechanism that links Histone H3 acetylation and H3K4me3. Proteoform mechanisims are crucial to gene transcription! #proteoforms #proteomics #epigenetics #chromatin #transcription doi.org/10.7554/eLife.…

I know some folks have seen our biorxiv post, but now I can happily say this paper is officially published! Thanks to all parties involved! An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability doi.org/10.7554/eLife.…

Vem participar!!! 😀 Please RT Eberlin Lab BCM_Surgery Am Soc for Mass Spec

I’m presenting our quantitative top down proteomic analysis of the histone proteoforms of the mouse brain at ASMS poster 531 today. #ASMS #CTDP #histones #proteoforms

Deeply saddened by the loss of Dr. Andy Alpert, a good friend, a longtime collaborator, and an honorary member of our group. 😭Andy was a brilliant scientist and a kind person. He made major contributions to #HPLC & #MS and helped so many Am Soc for Mass Spec #TeamMassSpec RIP, Andy!❤️🙏

Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress biorxiv.org/content/10.110…

We have an opening for a postdoc position in Top-Down Proteomics, Epigenetics, and Neurodegenerative disease. The position is open immediately. nature.com/naturecareers/… #Proteomics #Epigenetics #Chromatin #CTDP #Histones

Pleased to share this collab with Musselman Lab using BPTF to show how nucleosome context shapes combinatorial #chromatin interactions. Together these results support a redefining of the "histone code" using nucleosome substrates. hubs.la/Q02k9WMH0

Full text now out! Fantastic collaboration with EpiCypher, Inc. showing that nucleosome context matters for histone PTM readout, and that patterns of PTMs function both through direct readout and through conformational regulation eLife - the journal Department of Biochemistry and Molecular Genetics Department of Biochemistry and Molecular Biology doi.org/10.7554/eLife.…

Manuscript accepted email from #JMedChem = a very happy Friday! Congratulations to @kieramalone_klm and Margaret Phillips

Excited to share that our paper "Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains" is out in JMedChem! doi.org/10.1021/acs.jm… Details below 👇

Come join our team!!!! We are looking for highly motivated Postdoctoral Associates with interests in Proteomics and Chromatin Biology jobs.bcm.edu/job/Postdoctor…

Looking for motivated post-doctoral associates to tackle the proteoform biology of epigenetic and aging using top-down and bottom-up proteomics. Come join our team! nature.com/naturecareers/…

Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context and can describe how proteoforms are configured in functionally distinct complexes across biology. authors.elsevier.com/c/1lt5I3vVUPVb…