Open-source, high performance miniature 2-photon microscopy systems for freely behaving animals nature.com/articles/s4146…

A manifesto for #AlzheimersDisease drug discovery in the era of disease-modifying #therapies Heike Hering, Thierry Bussiere, Chia-Chen Liu...Dominic M. Walsh Biogen #amyloid #alphasynuclein #APOE …arneurodegeneration.biomedcentral.com/articles/10.11…

Did you know newborn brains contain high levels of Alzheimer’s proteins? Read about the surprising connection shown by Fernando Gonzalez-Ortiz that appeared in Brain Communications. Healthy newborns have much higher blood levels of phosphorylated tau217 or p-tau217 which is an

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway sciencedirect.com/science/articl…

Therapeutic genetic restoration through allogeneic brain microglia replacement nature.com/articles/s4158…

Microglia regulate neuronal activity via structural remodeling of astrocytes: Neuron cell.com/neuron/fulltex…

ApoE4 disrupts intracellular trafficking and iron homeostasis in a reproducible iPSC-based model of human brain endothelial cells: Stem Cell Reports cell.com/stem-cell-repo…

AAV vectors for specific and efficient gene expression in microglia cell.com/cell-reports-m…

#APOE genotype influences on the brain #metabolome of aging mice – role for #mitochondrial energetics in mechanisms of #resilience in APOE2 genotype Kamil Borkowski, Nuanyi Liang, Na Zhao...Rima Kaddurah-Daouk Duke Department of Medicine MetabolomicsUCDavis Mayo Clinic Neuro …arneurodegeneration.biomedcentral.com/articles/10.11…

Dual AAV vectors for efficient delivery of large transgenes nature.com/articles/s4159…

Changes to the ERC evaluation procedures: Background and rationale linkedin.com/pulse/changes-…

She lived to 117: what her genes and lifestyle tell us about longevity

A fresh supply of the immune cells that keep the brain tidy might one day help to treat a host of conditions, from ultra-rare genetic disorders to more familiar scourges, such as Alzheimer’s disease. go.nature.com/4pIDwn4

Evidence-based tips on getting better sleep: the primacy of circadian rhythm new feature nature nature.com/articles/d4158…

🎉🎉🎉 Today, we have a huge announcement to make: SAMSON is now free for non-commercial use! This includes all extensions for docking, simulating, animating, scripting, and much, much more. Precisely, we are making the entire SAMSON molecular design platform - SAMSON + every

Sample Size Calculation in Scientific Studies Download Link: frontiersin.org/journals/medic…

The evolving landscape of Alzheimer’s disease therapy: From Aβ to tau cell.com/cell/fulltext/…