Excited to see this out; nicely summarised by Mayo Florida AutoImmune Neurology Group. It’s a privilege to work with such great collaborators. I’m excited to now be applying these principles to cancer, with the aim of finding better biomarkers and treatments for one of the toughest challenges: brain cancer.

Thrilled to share our recent study, which highlights the risk of false AChR-IgG positivity by RIPA in clinical practice 🎯 Paola Chessa Elia Sechi Valentina Damato 👏🏻 neurology.org/doi/10.1212/WN…

Here is the latest paper from our group on cryo-EM structures of the human adult muscle nicotinic acetylcholine receptor in resting-like and desensitized states. This work was spearheaded by Anna Li in collaboration with David B Sauer doi.org/10.1016/j.celr…

Delighted to have contributed to this work. CMV’s influence on immune dynamics is profound and yet largely ignored in many immune studies. Here we characterise its effects in Melanoma patients receiving immune checkpoint blockade therapy. What a way to start a DPhil from Gustav!

Many congratulations to Professor Irani and all co-authors for winning the prestigious 2024 PNAS Cozzarelli Prize in Biomedical Science. 👏🧠 The winning paper was a collaboration between NDCN, The Department of Statistics, and the Mayo Clinic in Florida.

Huge congratulations to former BMA Foundation winners Professor Irani and Bo Sun for their award winning study 🏆

Online Now: Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma dlvr.it/TKgVhz

1/ Truly excited to share our new study that I had to privilege to co-lead during my PhD alongside great friends and collaborators Masashi Nomura, Kevin C. Johnson and Luciano Garofano, which was published Nature Genetics! nature.com/articles/s4158…

Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging of 13C-labelled glucose metabolism go.nature.com/4jWzft2

Advancing atmospheric solids analysis probe mass spectrometry! Congrats to Liwen Song! We show how optimising background, consumables & batch effects can significantly improve ASAP-MS data quality for clinical diagnostics. pubs.rsc.org/en/content/art…

Great to see the field moving so fast. Some very interesting findings. I am always struck by how dominant the autoantigen B cell responses are in autoimmune encephalitis! Even more so in GAD-AINS given the intracellular localisation. Interestingly, no mention of CD8s, TBC? 🤷🏻‍♂️

🧠 Autoimmune GFAP astrocytopathy: a large French cohort study (116 patients) reveals varied clinical presentations & long-term outcomes. Relapses were common but disability remained low in most cases. 🔗 pubmed.ncbi.nlm.nih.gov/40419703/ #Neuroimmunology #AutoimmuneEncephalitis #Neurology

📢 NEW RESEARCH: how the body’s own defenses can mistakenly turn against the brain in CASPR2-antibody encephalitis 🧠 The findings potentially open the door to more targeted treatments. Find out more 👉 tinyurl.com/2tftusd4 Bo Sun

An atlas of transcription factor-driven gene programs across human cells Teichlab biorxiv.org/content/10.110…

3/3 Now, £380,000 has been committed to four new projects improving daily life for children and young people after a brain tumour. You can read more about our Quality of Life Award as well as the four projects here: bit.ly/4jy1tJP

Hirano et al. define a novel neurological disease spectrum involving the LGI1–ADAM22/23 pathway, identifying ultra-rare biallelic LGI1 variants in developmental and epileptic encephalopathy, and a biallelic ADAM23 variant in lethal neonatal epilepsy. tinyurl.com/4cpc48fy

Check out our new paper on the Patient-acceptable symptom state (PASS) question in AChR MG! 🧠 A step forward in aligning clinical metrics with patient perception. Thanks to all co-authors for the wonderful teamwork Valentina Damato Bo Sun Silvia Falso onlinelibrary.wiley.com/doi/10.1111/en…

📣 This morning, the Rare Cancers Bill — led by Dr Scott Arthur MP (Edinburgh South West) 🌍🌈🌹 — passed its Committee Stage in the House of Commons! The Bill will now continue it's journey through Parliament and we’ll be there every step of the way ensuring your voices are heard bit.ly/3IaEgjE

Bellanti et al. have developed an ultrasensitive assay for periaxin, a biomarker of peripheral nerve demyelination. When used alongside existing tests, the assay has the potential to improve the clinical management of peripheral neuropathy. tinyurl.com/4rbwjh67

Online Now: Blood TCRs go to town with early NPC detection dlvr.it/TLsTk2