Now throw steroids into the mix

jnnp.bmj.com/content/early/…

The variety of options and patients is why, in my opinion, RCTs are unlikely to answer many of the pending therapeutic questions in autoimmune neurology.

We sought to identify the minimum prednisone dose and duration required to delay relapses. In our study of 109 children and adults with MOGAD, we found that 12.5 mg/day of prednisone in adults (0.16 mg/kg/day in kids) for >/3 months reduced the risk of relapse by 88% !!! 🧠👀

There is emerging data that early relapses in MOGAD increase the risk of a chronically relapsing disease course. Corticosteroids are highly effective treatment in MOGAD, but high dose long term exposure to steroids has an unacceptable side effect profile for our patients.

Brilliant work!! Such a Big achievement

Honour and pleasure to speak at the Moffitt Cancer Center Curren Foundation in Tampa tonight. An amazing organisation doing so much good in paraneoplastic diseases for our patients Mayo Clinic Mayo Clinic Neurology Residency in Florida Mayo ClinicNeuro

Such cool validation of LGI1-antibody pathogenicity …. Especially as these patients have distinctive seizures as their disease hallmark…..

Led by Adam with amazing contributions from many including Fintan Sheerin Nick Provine on X (that’s the first time I didn’t say Twitter!)

Exciting study from the group of my colleague Sarosh Irani AutoImmune Neurology Group!
They show that numerous biomarkers of neurodegenerative and neuroinflammatory diseases are detected in the brain-draining cervical lymph nodes, and in many cases in higher concentrations than blood!!! 🤩🤯😍👍🏻

A great paper led by SKWright
which emphasises the elegance of patient derived monoclonal antibodies in being able to ask clean, focused, scientific questions.

They are sufficient to cause frequent seizures in animals!

University of Sydney Sydney Health Kids Research Sydney Local Health District Sydney Children's Hospitals Network Fabienne Brilot Russell Dale The MOG Project The Sumaira Foundation MS Australia Neuroimmunology Australia ISNI-The International Society of Neuroimmunology International Women in MS #iWiMS AutoImmune Neurology Group Dr Benjamin P Trewin AnnekeVdWalt Associate Professor Mastura Monif Assoc Professor Vilija Jokubaitis Romain Marignier Jakob Theorell James Varley Adam Carsten Finke Alberto Vogrig Anne-Katrin Pröbstel @chill_scientist Elia Sechi Elias Sotirchos External link now open to apply and will close on May 5th!

usyd.wd3.myworkdayjobs.com/USYD_EXTERNAL_…

Cleaver et al. review the clinical presentation and immunobiology of brain disease caused by the herpes simplex virus, and discuss how relapses can be caused by immune reactions against neuronal proteins. tinyurl.com/p84u4xjd

You flatter us Stacey Clardy MD PhD 😊

Excellent session with case-based presentations on #autoimmuneencephalitis by leading experts in the field: AutoImmune Neurology Group and colleagues. #AAN2024

If u like cased-based autoimmune neurological dilemmas, pearls and controversies…..Please come to our session on April 14th at #AANAM

Very lucky to have Drs Brian Weinshenker and Chris Lamb as co speakers. Between us, we will cover the whole neuroaxis!

aan.com/msa/Public/Eve…

Delighted for you Cathrin- looks great!

Abstract submission deadline is May 1st!

See you all there! Eoin Flanagan Divyanshu Dubey Stacey Clardy MD PhD Spencer Hutto, MD

Come and join many of the worlds foremost experts in autoimmune neurological disorders #AAN

Two excellent physician researchers…..and collaborators! Safe travels

It all started there!!