1/14 How do diuretics lead to metabolic alkalosis? I often invoke "contraction alkalosis", typically as a hand-wave explanation as patients' bicarbonate increases with diuresis. Should I continue to wave my hands?

Fellow interns: What’s your favorite medication & dose and why is it Lasix 80?

“What is the role of vasopressin?” A nephrologist will talk about osmolality and aquaporins. An intensivist might talk about its use as a pressor. But, ask an evolutionary or social scientist and you might be surprised by the answer… #MedTwitter #NephTwitter #NSMC

It’s so not fun when your attending asks you to do antibiotic lock therapy at 5pm. #dialysis #clabsi

🔥 NEW 🔥 @jlbouchard001 has evolved from #Remdesivir Queen to #CovidVaccine Queen. I’m always incredibly proud of the work she does. Check out her superb educational videos on COVID vaccines on SIDP’s website & YouTube: sidp.org/covid19therape…

Can you dose #Vancomycin & hit AUC/MIC targets in HD patients? @SusanjoyLewis & I dosed & performed TDM in thousands of virtual patients to find out: Evaluation & Development of Vancomycin Dosing Schemes to Meet New AUC/MIC Targets in IHD pubmed.ncbi.nlm.nih.gov/32851685/

1/15 Why can cefepime cause neurological toxicity? And why is renal failure the main risk factor for this complication? The answer requires us to learn about cefepime's structure and why it unexpectedly binds to a certain CNS receptor. #MedTwitter #Tweetorial

Anddd this confirms what we suspected! Though the immune response is detected, the level of IgG antibodies is less among dialysis patients as opposed to healthy individuals. Risk factors for low IgG level includes older age. This is groundbreaking!

Very nicely done study! Even a low dose of prednisone 5 has an impact on Covid19 antibodies production!

This is a good question that I got many times in practice. RAASi in combination with DHP CCB can reduce peripheral edema. However the questions remain if this strategy works with all CCBs? Or just amlodipine. 🤔

70 year old woman on losartan and dapagliflozin. Patient has DM, HTN, CKD. eGFR 35, ACR 600. Complains of 3 UTI in the last 6 months. None documented by U/A or urine cxr.

7 ways the EMPA-KIDNEY trial will impact clinical care in CKD A Thread 🧵 Sources NEJM Nephrology Journal Club Diabetes Canada American Diabetes Association KDIGO European Society of Cardiology Journals Swapnil Hiremath @hswapnil.medsky.social Joel M. Topf, MD FACP

✅IT OUT 👇 📢📢📢Tweetorial Alert (1/19)! What is the most common complication of routine outpatient hemodialysis (HD) treatments?

This study is so much needed for pharmacists working in dialysis setting! Now we have a good evidence to support deprescribing to improve outcomes in outpatient dialysis setting. Maybe this can be a great tool for inpatient pharmacists too!

Hyperkalemia management: practice points in potassium control 🍌 KDIGO Nephrology Journal Club

Interesting data! I bet everyone here when we treat patients with worsening GFRs ( < 30 mL/min), we automatically stop metformin for a fear of lactic acidosis. However, this data from AJKD showed something different. ACCP Adult Med PRN ACCP Cardiology PRN ACCP Ambulatory Care PRN ACCPpostgrads more👇